Sökning: onr:"swepub:oai:lup.lub.lu.se:c3b49d92-c523-4dc3-8a45-bc67e97b3284" >
Molecular and patho...
-
Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Molecular and pathological characterization of inherited breast cancer.
- Artikel/kapitelEngelska2001
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:c3b49d92-c523-4dc3-8a45-bc67e97b3284
-
https://lup.lub.lu.se/record/1121626URI
-
https://doi.org/10.1006/scbi.2001.0393DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Bröstcancer-genetikSektion I
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Seminars in Cancer Biology: Elsevier BV11:5, s. 375-3851096-36501044-579X
Internetlänk
Hitta via bibliotek
Till lärosätets databas