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  • Huhn, StefanieGerman Cancer Research Centre,University Hospital Heidelberg (author)

Coding variants in NOD-like receptors : An association study on risk and survival of colorectal cancer

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-06-21
  • Public Library of Science (PLoS),2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c3f151a7-24e8-43eb-b18b-f9f7813a1b3c
  • https://lup.lub.lu.se/record/c3f151a7-24e8-43eb-b18b-f9f7813a1b3cURI
  • https://doi.org/10.1371/journal.pone.0199350DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were found to be associated with CRC risk and eight with survival at 5% significance level. In a replication analysis using data of two large genome-wide association studies (GWASs) from Germany (DACHS: 1798 cases and 1810 controls) and Scotland (2210 cases and 9350 controls) the associations found in the Czech discovery set were not confirmed. However, expression analysis in human gut-related tissues and immune cells revealed that the NLRs associated with CRC risk or survival in the discovery set were expressed in primary human colon or rectum cells, CRC tissue and/or cell lines, providing preliminary evidence for a potential involvement of NLRs in general in CRC development and/or progression. Most interesting was the finding that the enigmatic development-related NLRP5 (also known as MATER) was not expressed in normal colon tissue but in colon cancer tissue and cell lines. Future studies may show whether regulatory variants instead of coding variants might affect the expression of NLRs and contribute to CRC risk and survival.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • da Silva Filho, Miguel I.German Cancer Research Centre(Swepub:lu)med-md_ (author)
  • Sanmuganantham, TharmilaUniversity of Tübingen (author)
  • Pichulik, TicaUniversity of Tübingen (author)
  • Catalano, CalogerinaGerman Cancer Research Centre (author)
  • Pardini, BarbaraItalian Institute for Genomic Medicine (IIGM),Institute of Experimental Medicine, Czech Academy of Science (author)
  • Naccarati, AlessioInstitute of Experimental Medicine, Czech Academy of Science,Italian Institute for Genomic Medicine (IIGM) (author)
  • Polakova-Vymetálkova, VeronikaInstitute of Experimental Medicine, Czech Academy of Science,Charles University in Prague (author)
  • Jiraskova, KaterinaInstitute of Experimental Medicine, Czech Academy of Science,Charles University in Prague (author)
  • Vodickova, LudmilaCharles University in Prague,Institute of Experimental Medicine, Czech Academy of Science (author)
  • Vodicka, PavelInstitute of Experimental Medicine, Czech Academy of Science,Charles University in Prague (author)
  • Löffler, Markus W.University Hospital of Tubingen,University of Tübingen (author)
  • Courth, LiobaUniversity Hospital of Tubingen (author)
  • Wehkamp, JanUniversity Hospital of Tubingen (author)
  • Din, Farhat V.N.University of Edinburgh (author)
  • Timofeeva, MariaUniversity of Edinburgh (author)
  • Farrington, Susan M.University of Edinburgh (author)
  • Jansen, LinaGerman Cancer Research Centre (author)
  • Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Center for Primary Health Care Research(Swepub:lu)med-khk (author)
  • Chang-Claude, JennyGerman Cancer Research Centre (author)
  • Brenner, HermannGerman Cancer Research Centre (author)
  • Hoffmeister, MichaelGerman Cancer Research Centre (author)
  • Dunlop, Malcolm G.University of Edinburgh (author)
  • Weber, Alexander N.R.University of Tübingen (author)
  • Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Center for Primary Health Care Research(Swepub:lu)med-asf (author)
  • German Cancer Research CentreUniversity Hospital Heidelberg (creator_code:org_t)

Related titles

  • In:PLoS ONE: Public Library of Science (PLoS)13:61932-6203

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