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Genome-wide associa...
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
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Lascorz, Jesus (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Chen, Bowang (author)
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Buch, Stephan (author)
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Steinke, Verena (author)
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Rahner, Nils (author)
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Holinski-Feder, Elke (author)
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Morak, Monika (author)
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Schackert, Hans K. (author)
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Goergens, Heike (author)
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Schulmann, Karsten (author)
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Goecke, Timm (author)
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Kloor, Matthias (author)
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Engel, Cristoph (author)
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Buettner, Reinhard (author)
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Kunkel, Nelli (author)
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Weires, Marianne (author)
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Hoffmeister, Michael (author)
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Pardini, Barbara (author)
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Naccarati, Alessio (author)
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Vodickova, Ludmila (author)
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Novotny, Jan (author)
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Schreiber, Stefan (author)
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Krawczak, Michael (author)
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Broering, Clemens D. (author)
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Voelzke, Henry (author)
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Schafmayer, Clemens (author)
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Vodicka, Pavel (author)
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Chang-Claude, Jenny (author)
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Brenner, Hermann (author)
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Burwinkel, Barbara (author)
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Propping, Peter (author)
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Hampe, Jochen (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2010-07-07
- 2010
- English.
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 31:9, s. 1612-1619
- Related links:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in four additional case-control sets (4915 cases and 5607 controls). Known risk loci at 8q24.21 and 11q23 were confirmed, and a previously unreported association, rs12701937, located between the genes GLI3 (GLI family zinc finger 3) and INHBA (inhibin, beta A) [P = 1.1 x 10(-3), odds ratio (OR) 1.14, 95% confidence interval (CI) 1.05-1.23, dominant model in the combined cohort], was identified. The association was stronger in familial cases compared with unselected cases (P = 2.0 x 10(-4), OR 1.36, 95% CI 1.16-1.60, dominant model). Two other unreported SNPs, rs6038071, 40 kb upstream of CSNK2A1 (casein kinase 2, alpha 1 polypeptide) and an intronic marker in MYO3A (myosin IIIA), rs11014993, associated with CRC only in the familial CRC cases (P = 2.5 x 10(-3), recessive model, and P = 2.7 x 10(-4), dominant model). Three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS (allelic P value < 10(-3)). The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P-trend = 2.2 x 10(-16), ORper allele = 1.34, 95% CI 1.11-1.61).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Lascorz, Jesus
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Försti, Asta
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Chen, Bowang
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Buch, Stephan
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Steinke, Verena
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Rahner, Nils
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show more...
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Holinski-Feder, ...
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Morak, Monika
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Schackert, Hans ...
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Goergens, Heike
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Schulmann, Karst ...
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Goecke, Timm
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Kloor, Matthias
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Engel, Cristoph
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Buettner, Reinha ...
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Kunkel, Nelli
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Weires, Marianne
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Hoffmeister, Mic ...
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Pardini, Barbara
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Naccarati, Aless ...
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Vodickova, Ludmi ...
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Novotny, Jan
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Schreiber, Stefa ...
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Krawczak, Michae ...
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Broering, Clemen ...
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Voelzke, Henry
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Schafmayer, Clem ...
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Vodicka, Pavel
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Chang-Claude, Je ...
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Brenner, Hermann
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Burwinkel, Barba ...
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Propping, Peter
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Hampe, Jochen
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Hemminki, Kari
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Carcinogenesis
- By the university
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Lund University