Sökning: WFRF:(Wolkowitz Owen M.) >
Severity of anxiety...
Severity of anxiety– but not depression– is associated with oxidative stress in Major Depressive Disorder
-
- Steenkamp, Lisa R. (författare)
- Leiden University,University of California, San Francisco
-
- Hough, Christina M (författare)
- University of California, San Francisco,Leiden University
-
- Reus, Victor I (författare)
- University of California, San Francisco
-
visa fler...
-
- Jain, Felipe A (författare)
- University of California, San Francisco
-
- Epel, Elissa S (författare)
- University of California, San Francisco
-
- James, S Jill (författare)
- University of Arkansas for Medical Sciences
-
- Morford, Alexandra E. (författare)
- University of Texas Health Science Centre
-
- Mellon, Synthia H (författare)
- University of California, San Francisco
-
- Wolkowitz, Owen M (författare)
- University of California, San Francisco
-
- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, San Francisco
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
-
Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 219, s. 193-200
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Oxidative stress is implicated in both depression and anxiety, but it is currently unclear whether this relates to syndromal diagnoses or trans-diagnostic dimensional symptoms. We examined the relationship between oxidative stress and severity of depression and anxiety symptoms in individuals with Major Depressive Disorder (MDD). Methods Plasma oxidative stress markers F2-isoprostanes and oxidized glutathione (GSSG), and the antioxidant reduced glutathione (GSH), were assessed in 69 physically healthy, medication-free MDD subjects. Symptoms of anxiety and depression were assessed using the Hamilton Anxiety (HAM-A) and Hamilton Depression (HAM-D) Rating Scales. Total HAM-A and HAM-D scores, along with “core” anxiety and depression subscales, and individual HAM-D items “psychic anxiety” and “depressed mood,” were related to oxidative stress markers. Analyses controlled for age, sex, BMI, and smoking. Results Total HAM-A ratings were positively associated with F2-isoprostanes (β=.26, p=.042) and GSSG (β=.25, p=.049), but not GSH (β=.05, p=.711). Core anxiety severity was positively associated with F2-isoprostanes (β=.34, p=.012) and GSSG, although this did not reach significance (β=.24, p=.074). None of the biological markers were significantly associated with total HAM-D or core depression ratings (all p>.13). Subjects scoring high on “psychic anxiety” had elevated F2-isoprostanes (p=.030) and GSSG (p=.020). This was not seen with “depressed mood” scores (all p>.12). Limitations We assessed peripheral oxidative markers, but their relationship to the brain is unclear. Conclusions Oxidative stress is more closely related to anxiety than depression symptoms in MDD. This highlights the importance of relating oxidative stress to specific symptoms and could provide new insights into the biological correlates of affective disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Anxiety
- F2-isoprostanes
- Major Depressive Disorder
- Oxidative stress
- Oxidized glutathione
- Reduced glutathione
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Steenkamp, Lisa ...
-
Hough, Christina ...
-
Reus, Victor I
-
Jain, Felipe A
-
Epel, Elissa S
-
James, S Jill
-
visa fler...
-
Morford, Alexand ...
-
Mellon, Synthia ...
-
Wolkowitz, Owen ...
-
Lindqvist, Danie ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Journal of Affec ...
- Av lärosätet
-
Lunds universitet