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- Nutu, Magdalena (author)
Evaluation of the Cerebrospinal Fluid Amyloid-beta(1-42)/Amyloid-beta(1-40) Ratio Measured by Alpha-LISA to Distinguish Alzheimer's Disease from Other Dementia Disorders
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-07-09
- S. Karger AG,2013
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:c496ca1d-0235-41c2-a64c-f9cafb310b55
- https://lup.lub.lu.se/record/4272598URI
- https://doi.org/10.1159/000353442DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Background: The well-established core biomarkers used to identify Alzheimer's disease (AD) overlap with other dementia disorders such as dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-beta (A beta)(1-42)/A beta(1-40) ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD. Method: CSF levels of A beta(1-40) and A beta(1-42) in patients with PDD, DLB, AD, Parkinson's disease and controls were analyzed using an amplified luminescent proximity homogenous immunoassay along with conventional immunoassays. Results: The CSF A beta(1-42)/A beta(1-40) ratio increased discrimination of AD from PDD and DLB compared with either of the two A beta biomarkers individually. Conclusion: The use of the A beta(1-42)/A beta(1-40) ratio could improve the differentiation of AD from PDD and DLB. (C) 2013 S. Karger AG, Basel
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Amyloid-beta
- Alzheimer's disease
- Parkinson's disease
- Immunoassays
- Amplified luminescent proximity homogenous immunoassay
Added entries (persons, corporate bodies, meetings, titles ...)
- Zetterberg, Henrik (author)
- Londos, ElisabetLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)pski-elo (author)
- Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
- Nägga, KatarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-kng (author)
- Blennow, Kaj (author)
- Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
- Ohrfelt, Annika (author)
- Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Dementia and Geriatric Cognitive Disorders: S. Karger AG36:1-2, s. 99-1101420-80081421-9824
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