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Clinical and biolog...
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
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- Merrien, Magali (author)
- Karolinska Institutet
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- Wasik, Agata M. (author)
- Karolinska University Hospital
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- Ljung, Elin (author)
- Karolinska University Hospital
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- Morsy, Mohammad H.A. (author)
- Karolinska University Hospital
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- de Matos Rodrigues, Joana (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Carlsten, Mattias (author)
- Karolinska Institute,Karolinska University Hospital
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- Rassidakis, Georgios Z. (author)
- Karolinska Institutet,Karolinska Institute,University of Texas
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- Christensson, Birger (author)
- Karolinska Institutet
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- Kolstad, Arne (author)
- Norwegian Radium Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ek, Sara (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Herold, Nikolas (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wahlin, Björn E. (author)
- Karolinska University Hospital
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- Sander, Birgitta (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-11-04
- 2022
- English.
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In: Virchows Archiv. - : Springer Science and Business Media LLC. - 0945-6317 .- 1432-2307. ; 480:3, s. 655-666
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Abstract
Subject headings
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- SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment before autologous stem cell transplantation for younger patients with mantle cell lymphoma (MCL). We here investigated the expression of SAMHD1 in a population-based cohort of MCL (N = 150). SAMHD1 was highly variably expressed in MCL (range, 0.4% to 100% of positive tumor cells). Cases with blastoid/pleomorphic morphology had higher SAMHD1 expression (P = 0.028) and SAMHD1 was also correlated to tumor cell proliferation (P = 0.016). SAMHD1 expression showed moderate correlation to the expression of the transcriptional regulator SOX11 (P = 0.036) but genetic silencing of SOX11 and SAMHD1 by siRNA in MCL cell lines did not suggest mutual regulation. We hypothesized that expression of SAMHD1 could predict short time to progression in patients treated with Cytarabine as part of high-dose chemotherapy. Despite the correlation with known biological adverse prognostic factors, neither low or high SAMHD1 expression correlated to PFS or OS in patients treated according to the Nordic MCL2 or MCL3 protocols (N = 158).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Cytarabine
- Mantle cell lymphoma
- Prognostic factors
- SAMHD1
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Merrien, Magali
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Wasik, Agata M.
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Ljung, Elin
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Morsy, Mohammad ...
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de Matos Rodrigu ...
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Carlsten, Mattia ...
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show more...
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Rassidakis, Geor ...
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Christensson, Bi ...
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Kolstad, Arne
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Jerkeman, Mats
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Ek, Sara
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Herold, Nikolas
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Wahlin, Björn E.
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Sander, Birgitta
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Virchows Archiv
- By the university
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Lund University
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Karolinska Institutet