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- Carey, Jannette (author)
Protein reconstitution and three-dimensional domain swapping: Benefits and constraints of covalency
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Wiley,2007
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:c5221548-daf5-4514-b752-e4e00fcc57be
- https://lup.lub.lu.se/record/651797URI
- https://doi.org/10.1110/ps.072985007DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The phenomena of protein reconstitution and three-dimensional domain swapping reveal that highly similar structures can be obtained whether a protein is comprised of one or more polypeptide chains. In this review, we use protein reconstitution as a lens through which to examine the range of protein tolerance to chain interruptions and the roles of the primary structure in related features of protein structure and folding, including circular permutation, natively unfolded proteins, allostery, and amyloid fibril formation. The results imply that noncovalent interactions in a protein are sufficient to specify its structure under the constraints imposed by the covalent backbone.
Subject headings and genre
- NATURVETENSKAP Kemi Fysikalisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Physical Chemistry hsv//eng
- metastability
- stability
- steric constraints
- ligand
- cooperativity
- binding
Added entries (persons, corporate bodies, meetings, titles ...)
- Lindman, StinaLund University,Lunds universitet,Biofysikalisk kemi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biophysical Chemistry,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)bpc-sli (author)
- Bauer, MikaelLund University,Lunds universitet,Biofysikalisk kemi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biophysical Chemistry,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)bpc-mlb (author)
- Linse, SaraLund University,Lunds universitet,Biofysikalisk kemi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biophysical Chemistry,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fkm2-sli (author)
- Biofysikalisk kemiCentrum för Molekylär Proteinvetenskap (creator_code:org_t)
Related titles
- In:Protein Science: Wiley16:11, s. 2317-23331469-896X0961-8368
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