Effects of blood ΔR(2)* non-linearity on absolute perfusion quantification using DSC-MRI: Comparison with Xe-133 SPECT.

Knutsson, LindaLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups (författare)

PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to the arterial input function (AIF) and the venous output function (VOF) from DSC-MRI. To reduce partial volume effects in the AIF, the arterial time integral was rescaled using a corrected VOF scheme. RESULTS: Under the assumption of proportionality between the two modalities, the relationship CBF(MRI)=0.58CBF(SPECT) (r=0.64) was observed using the linear relationship and CBF(MRI)=0.51CBF(SPECT) (r=0.71) using the non-linear relationship. DISCUSSION: A smaller ratio of the VOF time integral to the AIF time integral and a somewhat better correlation between global DSC-MRI and Xe-133 SPECT CBF estimates were observed using the non-linear relationship. The results did not, however, confirm the superiority of one model over the other, potentially because realistic AIF signal data may well originate from a combination of blood and surrounding tissue.

Ståhlberg, FreddyLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-fst (författare)
Wirestam, RonnieLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-rwi (författare)
van Osch, Matthias JLeiden University Medical Centre (författare)
Medicinsk strålningsfysik, LundSektion V (creator_code:org_t)

Ingår i:Magnetic Resonance Imaging: Elsevier BV31:5, s. 651-6551873-58940730-725X

Av författaren/redakt...: Knutsson, Linda; Ståhlberg, Fredd ...; Wirestam, Ronnie; van Osch, Matthi ...

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