SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(Sanchez Maria Jose)) srt2:(2010-2014) pers:(Pala Valeria) pers:(Panico Salvatore)
 

Search: (WFRF:(Sanchez Maria Jose)) srt2:(2010-2014) pers:(Pala Valeria) pers:(Panico Salvatore) > Risk factors for ca...

  • Kaaks, Rudolf (author)

Risk factors for cancers of unknown primary site: Results from the prospective EPIC cohort

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-04-10
  • Wiley,2014

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c61e42f2-cf47-4ec3-a07e-0008d4cffc4c
  • https://lup.lub.lu.se/record/4699582URI
  • https://doi.org/10.1002/ijc.28874DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129762212URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94927URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Cancer of unknown primary site (CUP) may be called an orphan disease, as it is diagnosed when metastases are detected while the primary tumor typically remains undetected, and because little research has been done on its primary causes. So far, few epidemiological studies, if any, have addressed possible risk factors for CUP. We analyzed data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (N=476,940). During prospective follow-up, a total of 651 cases of incident cases of CUP were detected (ICD-O-2 code C809). Proportional hazards models were conducted to examine the associations of lifetime history of smoking habits, alcohol consumption, levels of education and anthropometric indices of adiposity with risk of being diagnosed with CUP. Risk of being diagnosed with CUP was strongly related to smoking, with a relative risk of 3.66 [95% C.I., 2.24-5.97] for current, heavy smokers (26+ cigarettes/day) compared to never smokers (adjusted for alcohol consumption, body mass index, waist circumference and level of education) and a relative risk of 5.12 [3.09-8.47] for cases with CUP who died within 12 months. For alcohol consumption and level of education, weaker associations were observed but attenuated and no longer statistically significant after adjusting for smoking and indices of obesity. Finally, risk of CUP was increased by approximately 30 per cent for subjects in the highest versus lowest quartiles of waist circumference. Our analyses provide further documentation, in addition to autopsy studies, that a substantial proportion of cancers of unknown primary site may have their origin in smoking-related tumors, in particular. What's new? When cancer appears as metastatic disease but no primary tumor can be observed, it's called cancer of unknown primary site. Little is known about the risk factors for this type of cancer. This study analyzed data from a European cohort and discovered a strong association between smoking and these cancers. Other risk factors they identified were drinking alcohol and being fat. This is the first epidemiological study of these type of cancers, and it strengthens the observations from autopsy studies that many of these cancers of unknown primary site stem from smoking-related tumors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sookthai, Disorn (author)
  • Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk (author)
  • Kraemer, Alwin (author)
  • Boeing, Heiner (author)
  • Wirfält, ElisabetLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-ewi (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Overvad, Kim (author)
  • Tjonneland, Anne (author)
  • Olsen, Anja (author)
  • Peeters, Petra H. (author)
  • Bueno-de-Mesquita, H. B. (As) (author)
  • Panico, Salvatore (author)
  • Pala, Valeria (author)
  • Vineis, Paolo (author)
  • Ramon Quiros, J. (author)
  • Ardanaz, Eva (author)
  • Sanchez, Maria-Jose (author)
  • Chirlaque, Maria-Dolores (author)
  • Larranaga, Nerea (author)
  • Brennan, Paul (author)
  • Trichopoulos, Dimitrios (author)
  • Trichopoulou, Antonia (author)
  • Lagiou, Pagona (author)
  • Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
  • Khaw, Kay-Tee (author)
  • Key, Timothy J. (author)
  • Riboli, Elio (author)
  • Canzian, Federico (author)
  • Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley135:10, s. 2475-24810020-71361097-0215

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view