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Eosinophilic and No...
Eosinophilic and Noneosinophilic Asthma : An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort
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- Heaney, Liam G. (författare)
- Queen's University Belfast
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- Perez de Llano, Luis (författare)
- University Hospital Lucus Augusti
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- Al-Ahmad, Mona (författare)
- Kuwait University
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- Backer, Vibeke (författare)
- University of Copenhagen
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- Busby, John (författare)
- Queen's University Belfast
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- Canonica, Giorgio Walter (författare)
- Humanitas Research Hospital,Humanitas University
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- Christoff, George C. (författare)
- Medical University of Sofia
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- Cosio, Borja G. (författare)
- Hospital Universitario Son Espases
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- FitzGerald, J. Mark (författare)
- Centre for Lung Health, Vancouver
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- Heffler, Enrico (författare)
- Humanitas Research Hospital,Humanitas University
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- Iwanaga, Takashi (författare)
- Kindai University Hospital
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- Jackson, David J. (författare)
- Guy's and St Thomas' NHS Foundation Trust,King's College London
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- Menzies-Gow, Andrew N. (författare)
- Royal Brompton and Harefield NHS Foundation Trust
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- Papadopoulos, Nikolaos G. (författare)
- National and Kapodistrian University of Athens
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- Papaioannou, Andriana I. (författare)
- National and Kapodistrian University of Athens
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- Pfeffer, Paul E. (författare)
- Queen Mary University
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Popov, Todor A. (författare)
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- Porsbjerg, Celeste M. (författare)
- Bispebjerg Hospital
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Rhee, Chin Kook (författare)
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- Sadatsafavi, Mohsen (författare)
- University of British Columbia
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Tohda, Yuji (författare)
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- Wang, Eileen (författare)
- University of Colorado School of Medicine,National Jewish Health
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- Wechsler, Michael E. (författare)
- National Jewish Health
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- Alacqua, Marianna (författare)
- AstraZeneca, UK
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- Altraja, Alan (författare)
- University of Tartu
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups,Skåne University Hospital
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- Björnsdóttir, Unnur S. (författare)
- National University Hospital of Iceland
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- Bourdin, Arnaud (författare)
- University of Montpellier
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- Brusselle, Guy G. (författare)
- Ghent University Hospital,Erasmus University Medical Center
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- Buhl, Roland (författare)
- Universitätsmedizin Mainz
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- Costello, Richard W. (författare)
- Beaumont Hospital, Dublin
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- Hew, Mark (författare)
- Monash University
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- Koh, Mariko Siyue (författare)
- Singapore General Hospital,Duke–NUS Medical School
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- Lehmann, Sverre (författare)
- University of Bergen
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- Lehtimäki, Lauri (författare)
- Tampere University Hospital
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- Peters, Matthew (författare)
- Concord Repatriation General Hospital
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- Taillé, Camille (författare)
- Paris Diderot University
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- Taube, Christian (författare)
- University Hospital Essen
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- Tran, Trung N. (författare)
- AstraZeneca, UK
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- Zangrilli, James (författare)
- AstraZeneca, UK
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- Bulathsinhala, Lakmini (författare)
- Optimum Patient Care Ltd
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- Carter, Victoria A. (författare)
- Optimum Patient Care Ltd
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- Chaudhry, Isha (författare)
- Optimum Patient Care Ltd
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- Eleangovan, Neva (författare)
- Optimum Patient Care Ltd
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- Hosseini, Naeimeh (författare)
- Optimum Patient Care Ltd
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- Kerkhof, Marjan (författare)
- Optimum Patient Care Ltd
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- Murray, Ruth B. (författare)
- Optimum Patient Care Ltd
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- Price, Chris A. (författare)
- Optimum Patient Care Ltd
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- Price, David B. (författare)
- University of Aberdeen,Observational and Pragmatic Research Institute Pte Ltd,Optimum Patient Care Ltd
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska 17 s.
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Ingår i: Chest. - : Elsevier BV. - 0012-3692. ; 160:3, s. 814-830
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://journal.chest...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). Results: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. Interpretation: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessible in real life), the severe asthma eosinophilic phenotype was more prevalent than previously identified and was phenotypically distinct. This pragmatic gradient algorithm uses variables readily accessible in primary and specialist care, addressing inherent issues of phenotype heterogeneity and phenotype instability. Identification of treatable traits across phenotypes should improve therapeutic precision.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asia
- Europe
- International Severe Asthma Registry
- Middle East
- North America
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Chest
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Till lärosätets databas
- Av författaren/redakt...
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Heaney, Liam G.
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Perez de Llano, ...
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Al-Ahmad, Mona
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Backer, Vibeke
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Busby, John
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Canonica, Giorgi ...
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visa fler...
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Christoff, Georg ...
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Cosio, Borja G.
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FitzGerald, J. M ...
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Heffler, Enrico
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Iwanaga, Takashi
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Jackson, David J ...
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Menzies-Gow, And ...
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Papadopoulos, Ni ...
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Papaioannou, And ...
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Pfeffer, Paul E.
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Popov, Todor A.
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Porsbjerg, Celes ...
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Rhee, Chin Kook
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Sadatsafavi, Moh ...
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Tohda, Yuji
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Wang, Eileen
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Wechsler, Michae ...
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Alacqua, Mariann ...
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Altraja, Alan
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Bjermer, Leif
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Björnsdóttir, Un ...
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Bourdin, Arnaud
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Brusselle, Guy G ...
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Buhl, Roland
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Costello, Richar ...
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Hew, Mark
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Koh, Mariko Siyu ...
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Lehmann, Sverre
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Lehtimäki, Lauri
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Peters, Matthew
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Taillé, Camille
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Taube, Christian
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Tran, Trung N.
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Zangrilli, James
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Bulathsinhala, L ...
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Carter, Victoria ...
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Chaudhry, Isha
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Eleangovan, Neva
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Hosseini, Naeime ...
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Kerkhof, Marjan
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Murray, Ruth B.
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Price, Chris A.
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Price, David B.
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