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Predictive value of...
Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts
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- Westbury, Leo D. (author)
- University of Southampton
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- Harvey, Nicholas C. (author)
- University of Southampton
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Beaudart, Charlotte (author)
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- Bruyère, Olivier (author)
- University of Liège
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- Cauley, Jane A. (author)
- University of Pittsburgh
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- Cawthon, Peggy (author)
- University of California, San Francisco,California Pacific Medical Center
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- Cruz-Jentoft, Alfonso J. (author)
- Hospital Ramón Y Cajal
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- Curtis, Elizabeth M. (author)
- University of Southampton
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- Ensrud, Kristine (author)
- University of Minnesota,Minneapolis VA Health Care System
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- Fielding, Roger A. (author)
- Jean Mayer USDA Human Nutrition Research Center on Aging
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- Johansson, Helena (author)
- University of Gothenburg,Australian Catholic University
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- Kanis, John A. (author)
- University of Sheffield,Australian Catholic University
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- Karlsson, Magnus K. (author)
- Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups,Skåne University Hospital
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- Lane, Nancy E. (author)
- University of California, Davis
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- Lengelé, Laetitia (author)
- Catholic University of Louvain
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- Lorentzon, Mattias (author)
- Sahlgrenska University Hospital,Australian Catholic University
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- McCloskey, Eugene (author)
- Australian Catholic University,University of Sheffield
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- Mellström, Dan (author)
- Sahlgrenska Academy
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- Newman, Anne B. (author)
- University of Pittsburgh
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- Ohlsson, Claes (author)
- Sahlgrenska University Hospital,Sahlgrenska Academy
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- Orwoll, Eric (author)
- Oregon Health & Science University
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Reginster, Jean Yves (author)
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- Ribom, Eva (author)
- Uppsala University
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- Rosengren, Björn E. (author)
- Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopedics,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Schousboe, John T. (author)
- University of Minnesota
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- Dennison, Elaine M. (author)
- University of Southampton,Te Herenga Waka / Victoria University of Wellington
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- Cooper, Cyrus (author)
- University of Southampton,University of Oxford
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Aging clinical and experimental research. - 1594-0667. ; 36:1
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell’s Concordance Index (C-index). Results: Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed. Conclusions: Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Ageing
- Epidemiology
- Mortality
- Osteoporosis
- Sarcopenia
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Westbury, Leo D.
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Harvey, Nicholas ...
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Beaudart, Charlo ...
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Bruyère, Olivier
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Cauley, Jane A.
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Cawthon, Peggy
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show more...
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Cruz-Jentoft, Al ...
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Curtis, Elizabet ...
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Ensrud, Kristine
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Fielding, Roger ...
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Johansson, Helen ...
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Kanis, John A.
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Karlsson, Magnus ...
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Lane, Nancy E.
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Lengelé, Laetiti ...
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Lorentzon, Matti ...
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McCloskey, Eugen ...
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Mellström, Dan
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Newman, Anne B.
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Ohlsson, Claes
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Orwoll, Eric
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Reginster, Jean ...
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Ribom, Eva
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Rosengren, Björn ...
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Schousboe, John ...
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Dennison, Elaine ...
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Cooper, Cyrus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Aging clinical a ...
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Lund University