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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott, Paul A (author)
Lee, Catherine (author)
Zichner, Thomas (author)
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Stütz, Adrian M (author)
Erkek, Serap (author)
Kawauchi, Daisuke (author)
Shih, David J H (author)
Hovestadt, Volker (author)
Zapatka, Marc (author)
Sturm, Dominik (author)
Jones, David T W (author)
Kool, Marcel (author)
Remke, Marc (author)
Cavalli, Florence M G (author)
Zuyderduyn, Scott (author)
Bader, Gary D (author)
VandenBerg, Scott (author)
Esparza, Lourdes Adriana (author)
Ryzhova, Marina (author)
Wang, Wei (author)
Wittmann, Andrea (author)
Stark, Sebastian (author)
Sieber, Laura (author)
Seker-Cin, Huriye (author)
Linke, Linda (author)
Kratochwil, Fabian (author)
Jäger, Natalie (author)
Buchhalter, Ivo (author)
Imbusch, Charles D (author)
Zipprich, Gideon (author)
Raeder, Benjamin (author)
Schmidt, Sabine (author)
Diessl, Nicolle (author)
Wolf, Stephan (author)
Wiemann, Stefan (author)
Brors, Benedikt (author)
Lawerenz, Chris (author)
Eils, Jürgen (author)
Warnatz, Hans-Jörg (author)
Risch, Thomas (author)
Yaspo, Marie-Laure (author)
Weber, Ursula D (author)
Bartholomae, Cynthia C (author)
von Kalle, Christof (author)
Turányi, Eszter (author)
Hauser, Peter (author)
Sandén, Emma (author)
Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Darabi, Anna (author)
Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Siesjö, Peter (author)
Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Sterba, Jaroslav (author)
Zitterbart, Karel (author)
Sumerauer, David (author)
van Sluis, Peter (author)
Versteeg, Rogier (author)
Volckmann, Richard (author)
Koster, Jan (author)
Schuhmann, Martin U (author)
Ebinger, Martin (author)
Grimes, H Leighton (author)
Robinson, Giles W (author)
Gajjar, Amar (author)
Mynarek, Martin (author)
von Hoff, Katja (author)
Rutkowski, Stefan (author)
Pietsch, Torsten (author)
Scheurlen, Wolfram (author)
Felsberg, Jörg (author)
Reifenberger, Guido (author)
Kulozik, Andreas E (author)
von Deimling, Andreas (author)
Witt, Olaf (author)
Eils, Roland (author)
Gilbertson, Richard J (author)
Korshunov, Andrey (author)
Taylor, Michael D (author)
Lichter, Peter (author)
Korbel, Jan O (author)
Wechsler-Reya, Robert J (author)
Pfister, Stefan M (author)
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 (creator_code:org_t)
2014-06-22
2014
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 511:7510, s. 428-428
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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By the author/editor
Northcott, Paul ...
Lee, Catherine
Zichner, Thomas
Stütz, Adrian M
Erkek, Serap
Kawauchi, Daisuk ...
show more...
Shih, David J H
Hovestadt, Volke ...
Zapatka, Marc
Sturm, Dominik
Jones, David T W
Kool, Marcel
Remke, Marc
Cavalli, Florenc ...
Zuyderduyn, Scot ...
Bader, Gary D
VandenBerg, Scot ...
Esparza, Lourdes ...
Ryzhova, Marina
Wang, Wei
Wittmann, Andrea
Stark, Sebastian
Sieber, Laura
Seker-Cin, Huriy ...
Linke, Linda
Kratochwil, Fabi ...
Jäger, Natalie
Buchhalter, Ivo
Imbusch, Charles ...
Zipprich, Gideon
Raeder, Benjamin
Schmidt, Sabine
Diessl, Nicolle
Wolf, Stephan
Wiemann, Stefan
Brors, Benedikt
Lawerenz, Chris
Eils, Jürgen
Warnatz, Hans-Jö ...
Risch, Thomas
Yaspo, Marie-Lau ...
Weber, Ursula D
Bartholomae, Cyn ...
von Kalle, Chris ...
Turányi, Eszter
Hauser, Peter
Sandén, Emma
Darabi, Anna
Siesjö, Peter
Sterba, Jaroslav
Zitterbart, Kare ...
Sumerauer, David
van Sluis, Peter
Versteeg, Rogier
Volckmann, Richa ...
Koster, Jan
Schuhmann, Marti ...
Ebinger, Martin
Grimes, H Leight ...
Robinson, Giles ...
Gajjar, Amar
Mynarek, Martin
von Hoff, Katja
Rutkowski, Stefa ...
Pietsch, Torsten
Scheurlen, Wolfr ...
Felsberg, Jörg
Reifenberger, Gu ...
Kulozik, Andreas ...
von Deimling, An ...
Witt, Olaf
Eils, Roland
Gilbertson, Rich ...
Korshunov, Andre ...
Taylor, Michael ...
Lichter, Peter
Korbel, Jan O
Wechsler-Reya, R ...
Pfister, Stefan ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Surgery
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
Articles in the publication
Nature
By the university
Lund University

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