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Laser ablation-indu...
Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma
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- Tisza, Anna (author)
- Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Klikovits, Thomas (author)
- Medical University of Vienna
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Benej, Michal (author)
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- Torok, Szilvia (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Szeitz, Beata (author)
- Semmelweis University
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- Valko, Zsuzsanna (author)
- Medical University of Vienna
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- Hoda, Mir Alireza (author)
- Medical University of Vienna
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- Hegedus, Balazs (author)
- Semmelweis University,University of Duisburg-Essen
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- Bonta, Maximilian (author)
- Technical University Vienna (TU Wien)
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- Nischkauer, Winfried (author)
- Technical University Vienna (TU Wien)
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- Hoetzenecker, Konrad (author)
- Medical University of Vienna
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- Limbeck, Andreas (author)
- Technical University Vienna (TU Wien)
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- Schelch, Karin (author)
- Medical University of Vienna
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- Laszlo, Viktoria (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna
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- Megyesfalvi, Zsolt (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,National Institute of Oncology, Budapest
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- Dome, Balazs (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: British Journal of Clinical Pharmacology. - 0306-5251. ; 89:11, s. 3364-3374
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Abstract
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- Aims: Pleural mesothelioma (PM) is a highly aggressive thoracic tumour with poor prognosis. Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM. Methods: We assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt-based chemotherapy (CHT). Pt levels and tissue distributions were measured by laser ablation-inductively coupled plasma-mass spectrometry and correlated with clinicopathological features. Results: In surgically resected PM specimens, mean Pt levels of nontumourous (fibrotic) areas were significantly higher (vs tumourous regions, P = 0.0031). No major heterogeneity of Pt distribution was seen within the tumourous areas. Pt levels correlated neither with the microvessel area nor with apoptosis rate in the tumourous or nontumourous regions. A significant positive correlation was found between serum and both full tissue section and tumourous area mean Pt levels (r = 0.532, P = 0.006, 95% confidence interval [95% CI] 0.161-0.771 and r = 0.415, P = 0.039, 95% CI 0.011-0.702, respectively). Furthermore, a significant negative correlation was detected between serum Pt concentrations and elapsed time from the last cycle of CHT (r = −0.474, P = 0.017, 95% CI −0.738-−0.084). Serum Pt levels correlated negatively with overall survival (OS) (P = 0.029). Conclusions: There are major differences in drug distribution between tumourous and nontumourous areas of PM specimens. Serum Pt levels significantly correlate with full section and tumourous area average Pt levels, elapsed time from the last CHT cycle, and OS. Further studies investigating clinicopathological factors that modulate tissue Pt concentration and distribution are warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- intratumoural drug distribution
- laser ablation-inductively coupled plasma-mass spectrometry
- mass spectrometry imaging
- neoadjuvant chemotherapy
- platinum
- pleural mesothelioma
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tisza, Anna
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Klikovits, Thoma ...
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Benej, Michal
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Torok, Szilvia
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Szeitz, Beata
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Valko, Zsuzsanna
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show more...
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Hoda, Mir Alirez ...
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Hegedus, Balazs
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Bonta, Maximilia ...
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Nischkauer, Winf ...
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Hoetzenecker, Ko ...
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Limbeck, Andreas
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Schelch, Karin
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Laszlo, Viktoria
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Megyesfalvi, Zso ...
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Dome, Balazs
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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British Journal ...
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Lund University