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Lessons learned fro...
Lessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised
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- Bergman, Michael (författare)
- NYU Langone
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- Jagannathan, Ram (författare)
- Emory University
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- Buysschaert, Martin (författare)
- Catholic University of Louvain,Saint-Luc University Hospital
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- Pareek, Manan (författare)
- Holbæk Hospital,Odense University Hospital,University of Southern Denmark
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- Olsen, Michael H. (författare)
- Odense University Hospital,Holbæk Hospital,University of Southern Denmark
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Medina, José Luis (författare)
- Oporto University
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- Roth, Jesse (författare)
- Feinstein Institute for Medical Research
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- Chetrit, Angela (författare)
- Gertner Institute for Epidemiology and Health Policy Research
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Dankner, Rachel (författare)
- Tel-Aviv University
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(creator_code:org_t)
- 2018-03-24
- 2018
- Engelska.
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Ingår i: Diabetes/Metabolism Research and Reviews. - : Wiley. - 1520-7552. ; 34:5
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value ≥155 mg/dl (8.6 mmol/L) may identify individuals with reduced β-cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA1c or 2-hour post-load glucose values. An elevated 1-hour post-load glucose level was a better predictor of type 2 diabetes than isolated 2-hour post-load levels in Indian, Japanese, and Israeli and Nordic populations. Furthermore, epidemiological studies have shown that a 1-hour PG ≥155 mg/dl (8.6 mmol/L) predicted progression to diabetes as well as increased risk for microvascular disease and mortality when the 2-hour level was <140 mg/dl (7.8 mmol/L). The risk of myocardial infarction or fatal ischemic heart disease was also greater among subjects with elevated 1-hour glucose levels as were risks of retinopathy and peripheral vascular complications in a Swedish cohort. The authors believe that the considerable evidence base supports redefining current screening and diagnostic recommendations with the 1-hour post-load level. Measurement of the 1-hour PG level would increase the likelihood of identifying a larger, high-risk group with the additional practical advantage of potentially replacing the conventional 2-hour oral glucose tolerance test making it more acceptable in a clinical setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Diabetes
- HbA
- Impaired fasting glucose
- Impaired glucose tolerance
- Oral glucose tolerance test
- Prediabetes
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Bergman, Michael
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Jagannathan, Ram
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Buysschaert, Mar ...
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Pareek, Manan
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Olsen, Michael H ...
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Nilsson, Peter M ...
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visa fler...
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Medina, José Lui ...
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Roth, Jesse
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Chetrit, Angela
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Groop, Leif
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Dankner, Rachel
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