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Lessons learned fro...
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Bergman, MichaelNYU Langone
(författare)
Lessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:c725f938-0a73-464a-93d3-32b77ebf38b3
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https://lup.lub.lu.se/record/c725f938-0a73-464a-93d3-32b77ebf38b3URI
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https://doi.org/10.1002/dmrr.2992DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value ≥155 mg/dl (8.6 mmol/L) may identify individuals with reduced β-cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA1c or 2-hour post-load glucose values. An elevated 1-hour post-load glucose level was a better predictor of type 2 diabetes than isolated 2-hour post-load levels in Indian, Japanese, and Israeli and Nordic populations. Furthermore, epidemiological studies have shown that a 1-hour PG ≥155 mg/dl (8.6 mmol/L) predicted progression to diabetes as well as increased risk for microvascular disease and mortality when the 2-hour level was <140 mg/dl (7.8 mmol/L). The risk of myocardial infarction or fatal ischemic heart disease was also greater among subjects with elevated 1-hour glucose levels as were risks of retinopathy and peripheral vascular complications in a Swedish cohort. The authors believe that the considerable evidence base supports redefining current screening and diagnostic recommendations with the 1-hour post-load level. Measurement of the 1-hour PG level would increase the likelihood of identifying a larger, high-risk group with the additional practical advantage of potentially replacing the conventional 2-hour oral glucose tolerance test making it more acceptable in a clinical setting.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jagannathan, RamEmory University
(författare)
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Buysschaert, MartinCatholic University of Louvain,Saint-Luc University Hospital
(författare)
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Pareek, MananHolbæk Hospital,Odense University Hospital,University of Southern Denmark
(författare)
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Olsen, Michael H.Odense University Hospital,Holbæk Hospital,University of Southern Denmark
(författare)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni
(författare)
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Medina, José LuisOporto University
(författare)
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Roth, JesseFeinstein Institute for Medical Research
(författare)
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Chetrit, AngelaGertner Institute for Epidemiology and Health Policy Research
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)endo-lgr
(författare)
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Dankner, RachelTel-Aviv University
(författare)
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NYU LangoneEmory University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes/Metabolism Research and Reviews: Wiley34:51520-7552
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Bergman, Michael
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Jagannathan, Ram
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Buysschaert, Mar ...
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Pareek, Manan
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Olsen, Michael H ...
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Nilsson, Peter M ...
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visa fler...
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Medina, José Lui ...
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Roth, Jesse
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Chetrit, Angela
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Groop, Leif
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Dankner, Rachel
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