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  • Bergman, MichaelNYU Langone (författare)

Lessons learned from the 1-hour post-load glucose level during OGTT : Current screening recommendations for dysglycaemia should be revised

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-03-24
  • Wiley,2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:c725f938-0a73-464a-93d3-32b77ebf38b3
  • https://lup.lub.lu.se/record/c725f938-0a73-464a-93d3-32b77ebf38b3URI
  • https://doi.org/10.1002/dmrr.2992DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value ≥155 mg/dl (8.6 mmol/L) may identify individuals with reduced β-cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA1c or 2-hour post-load glucose values. An elevated 1-hour post-load glucose level was a better predictor of type 2 diabetes than isolated 2-hour post-load levels in Indian, Japanese, and Israeli and Nordic populations. Furthermore, epidemiological studies have shown that a 1-hour PG ≥155 mg/dl (8.6 mmol/L) predicted progression to diabetes as well as increased risk for microvascular disease and mortality when the 2-hour level was <140 mg/dl (7.8 mmol/L). The risk of myocardial infarction or fatal ischemic heart disease was also greater among subjects with elevated 1-hour glucose levels as were risks of retinopathy and peripheral vascular complications in a Swedish cohort. The authors believe that the considerable evidence base supports redefining current screening and diagnostic recommendations with the 1-hour post-load level. Measurement of the 1-hour PG level would increase the likelihood of identifying a larger, high-risk group with the additional practical advantage of potentially replacing the conventional 2-hour oral glucose tolerance test making it more acceptable in a clinical setting.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jagannathan, RamEmory University (författare)
  • Buysschaert, MartinCatholic University of Louvain,Saint-Luc University Hospital (författare)
  • Pareek, MananHolbæk Hospital,Odense University Hospital,University of Southern Denmark (författare)
  • Olsen, Michael H.Odense University Hospital,Holbæk Hospital,University of Southern Denmark (författare)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni (författare)
  • Medina, José LuisOporto University (författare)
  • Roth, JesseFeinstein Institute for Medical Research (författare)
  • Chetrit, AngelaGertner Institute for Epidemiology and Health Policy Research (författare)
  • Groop, LeifLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)endo-lgr (författare)
  • Dankner, RachelTel-Aviv University (författare)
  • NYU LangoneEmory University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes/Metabolism Research and Reviews: Wiley34:51520-7552

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