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A multicentre valid...
A multicentre validation study of the diagnostic value of plasma neurofilament light
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Janelidze, Shorena (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Al Khleifat, Ahmad (author)
- King's College Hospital
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- Leuzy, Antoine (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Lycke, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Benedet, Andrea L (author)
- McGill University Research Centre for Studies in Aging
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- Pascoal, Tharick A (author)
- McGill University Research Centre for Studies in Aging
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- Lleó, Alberto (author)
- CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Parnetti, Lucilla (author)
- University of Perugia
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- Galimberti, Daniela (author)
- Maggiore Hospital Policlinico
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- Bonanni, Laura (author)
- University G.d'Annunzio of Chieti-Pescara
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- Pilotto, Andrea (author)
- University of Brescia
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- Padovani, Alessandro (author)
- University of Brescia
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- Lycke, Jan (author)
- University of Gothenburg
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- Novakova, Lenka, 1984 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Axelsson, Markus, 1975 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Velayudhan, Latha (author)
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Rabinovici, Gil D (author)
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Miller, Bruce (author)
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Pariante, Carmine (author)
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Nikkheslat, Naghmeh (author)
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Resnick, Susan M (author)
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Thambisetty, Madhav (author)
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- Schöll, Michael (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,University College London,Sahlgrenska Academy,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fernández-Eulate, Gorka (author)
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Gil-Bea, Francisco J (author)
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López de Munain, Adolfo (author)
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Al-Chalabi, Ammar (author)
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Rosa-Neto, Pedro (author)
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Strydom, Andre (author)
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- Svenningsson, Per (author)
- Karolinska Institutet,Karolinska Institute,King's College London
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- Stomrud, Erik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Santillo, Alexander (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Aarsland, Dag (author)
- Karolinska Institutet
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van Swieten, John C (author)
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- Palmqvist, Sebastian (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hye, Abdul (author)
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2021-06-07
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12, s. 1-12
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Age Factors
- Aged
- Biomarkers/cerebrospinal fluid
- Cognitive Dysfunction/cerebrospinal fluid
- Cohort Studies
- Depression/cerebrospinal fluid
- Down Syndrome/cerebrospinal fluid
- False Positive Reactions
- Female
- Humans
- Male
- Middle Aged
- Neurodegenerative Diseases/cerebrospinal fluid
- Neurofilament Proteins/cerebrospinal fluid
- Predictive Value of Tests
- Reference Values
- Sex Factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Ashton, Nicholas ...
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Janelidze, Shore ...
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Al Khleifat, Ahm ...
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Leuzy, Antoine
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Lycke, Jan, 1956
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Karikari, Thomas
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show more...
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Benedet, Andrea ...
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Pascoal, Tharick ...
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Lleó, Alberto
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Parnetti, Lucill ...
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Galimberti, Dani ...
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Bonanni, Laura
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Pilotto, Andrea
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Padovani, Alessa ...
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Lycke, Jan
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Novakova, Lenka, ...
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Axelsson, Markus ...
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Velayudhan, Lath ...
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Rabinovici, Gil ...
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Miller, Bruce
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Pariante, Carmin ...
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Nikkheslat, Nagh ...
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Resnick, Susan M
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Thambisetty, Mad ...
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Schöll, Michael
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Fernández-Eulate ...
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Gil-Bea, Francis ...
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López de Munain, ...
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Al-Chalabi, Amma ...
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Rosa-Neto, Pedro
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Strydom, Andre
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Svenningsson, Pe ...
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Stomrud, Erik
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Santillo, Alexan ...
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Aarsland, Dag
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van Swieten, Joh ...
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Palmqvist, Sebas ...
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Zetterberg, Henr ...
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Blennow, Kaj
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Hye, Abdul
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Hansson, Oskar
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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University of Gothenburg
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Karolinska Institutet