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  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)

A multicentre validation study of the diagnostic value of plasma neurofilament light

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-06-07
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c7b47565-6a88-4b98-8e2b-3ae63b1edbf0
  • https://lup.lub.lu.se/record/c7b47565-6a88-4b98-8e2b-3ae63b1edbf0URI
  • https://doi.org/10.1038/s41467-021-23620-zDOI
  • https://gup.ub.gu.se/publication/305344URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155243877URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:234099648URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147047977URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Janelidze, ShorenaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)nkir-sje (author)
  • Al Khleifat, AhmadKing's College Hospital (author)
  • Leuzy, AntoineLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)an3415le (author)
  • Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xlycja (author)
  • Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit (author)
  • Benedet, Andrea LMcGill University Research Centre for Studies in Aging (author)
  • Pascoal, Tharick AMcGill University Research Centre for Studies in Aging (author)
  • Lleó, AlbertoCIBER Enfermedades Neurodegenerativas (CIBERNED) (author)
  • Parnetti, LucillaUniversity of Perugia (author)
  • Galimberti, DanielaMaggiore Hospital Policlinico (author)
  • Bonanni, LauraUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Pilotto, AndreaUniversity of Brescia (author)
  • Padovani, AlessandroUniversity of Brescia (author)
  • Lycke, JanUniversity of Gothenburg (author)
  • Novakova, Lenka,1984Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xnovle (author)
  • Axelsson, Markus,1975Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xaxmar (author)
  • Velayudhan, Latha (author)
  • Rabinovici, Gil D (author)
  • Miller, Bruce (author)
  • Pariante, Carmine (author)
  • Nikkheslat, Naghmeh (author)
  • Resnick, Susan M (author)
  • Thambisetty, Madhav (author)
  • Schöll, MichaelGothenburg University,Göteborgs universitet,University of Gothenburg,University College London,Sahlgrenska Academy,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xschom (author)
  • Fernández-Eulate, Gorka (author)
  • Gil-Bea, Francisco J (author)
  • López de Munain, Adolfo (author)
  • Al-Chalabi, Ammar (author)
  • Rosa-Neto, Pedro (author)
  • Strydom, Andre (author)
  • Svenningsson, PerKarolinska Institutet,Karolinska Institute,King's College London(Swepub:lu)milj-psv (author)
  • Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr (author)
  • Santillo, AlexanderLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-ast (author)
  • Aarsland, DagKarolinska Institutet (author)
  • van Swieten, John C (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-spa (author)
  • Zetterberg, HenrikGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Blennow, KajGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Hye, Abdul (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Göteborgs universitetWallenberg Centre for Molecular and Translational Medicine (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC12, s. 1-122041-1723

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