Altered Sarcomeric Structure and Function in Woody Breast Myopathy of Avian Pectoralis Major Muscle

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Liu, JiaoLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,South Central University for Nationalities (author)

Altered Sarcomeric Structure and Function in Woody Breast Myopathy of Avian Pectoralis Major Muscle

Article/chapterEnglish2020

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2020-04-09
Frontiers Media SA,2020

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LIBRIS-ID:oai:lup.lub.lu.se:c8057174-ef3e-4b42-b192-2907c40c570a
https://lup.lub.lu.se/record/c8057174-ef3e-4b42-b192-2907c40c570aURI
https://doi.org/10.3389/fphys.2020.00287DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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The “Woody” or “Wooden” breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher. Although of significant ethical and economic impact, little is known regarding the structural and functional aspects of the contractile apparatus in the woody breast muscle. The aim of the present study was to determine physiological properties of the contractile system in the morphologically intact muscle fibers of focally damaged woody breast in comparison with normal muscle fibers to gain insight into the muscle function of the animal and possibly mechanisms involved in the disease development. Muscle samples were taken from woody breast (non-lesioned areas) and normal breast muscles from broilers. Length-tension curves, maximal active stress, maximal shortening velocity, calcium sensitivity, rate of tension development, lattice spacing and muscle biochemical composition were investigated on single skinned fibers. Sarcomeres of woody breast fibers were more compliant, which is very likely related to the wider spacing (18% wider compared to controls) between thick and thin filament. No differences were found in optimal sarcomere length (2.68 ± 0.04 vs. 2.65 ± 0.05 μm) nor in maximal active stress (116 ± 17 vs. 125 ± 19 mN mm–2). However, woody breast fibers had less steep descending arm as shown in length-tension curve. Woody breast muscle fibers had 40% bigger sarcomeric volume compared to controls. Content of contractile proteins (myosin and actin), and maximal shortening velocity were unchanged indicating that the growth in woody breast muscle fiber was associated with synthesis of new contractile units with unaltered kinetics. Calcium sensitivity was decreased in woody breast muscle fibers significantly. In conclusion, the results show that the rapid growth of muscle in woody breast disease is associated with significant structural and functional changes in the pectoralis major musculature, associated with alterations in the mechanical anchoring of contractile filaments.

Subject headings and genre

LANTBRUKSVETENSKAPER Husdjursvetenskap Husdjursvetenskap hsv//swe
AGRICULTURAL SCIENCES Animal and Dairy Sience Animal and Dairy Science. hsv//eng
NATURVETENSKAP Biologi Zoologi hsv//swe
NATURAL SCIENCES Biological Sciences Zoology hsv//eng
avian muscle
hypertrophy
muscle disease
muscular dystrophy
sarcomere

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Puolanne, EeroUniversity of Helsinki (author)
Schwartzkopf, MatthiasGerman Electron Synchrotron (DESY) (author)
Arner, AndersLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)an8151ar (author)
ThoraxkirurgiSektion II (creator_code:org_t)

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In:Frontiers in Physiology: Frontiers Media SA111664-042X

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By the author/editor: Liu, Jiao; Puolanne, Eero; Schwartzkopf, Ma ...; Arner, Anders

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AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Animal and Dairy ...; and Animal and Dairy ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Zoology

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By the university: Lund University

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