WFRF:(Bläckberg Anna)
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- Bläckberg, AnnaLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Skåne University Hospital (author)
Antibody kinetics and clinical course of COVID-19 a prospective observational study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-03-22
- Public Library of Science (PLoS),2021
- electronicrdacarrier
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- LIBRIS-ID:oai:lup.lub.lu.se:c8524964-64c0-4079-a591-8bdcb1f93fca
- https://lup.lub.lu.se/record/c8524964-64c0-4079-a591-8bdcb1f93fcaURI
- https://doi.org/10.1371/journal.pone.0248918DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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- Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV- 2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
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- Fernström, NilsLund University (author)
- Sarbrant, EmmaLund University (author)
- Rasmussen, MagnusLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-mra (author)
- Sunnerhagen, TorgnyLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Region Skåne(Swepub:lu)med-tsh (author)
- Translationell infektionsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:PLoS ONE: Public Library of Science (PLoS)16:3 March1932-6203
Internet link
- https://portal.research.lu.se/files/119180276/Antibody_kinetics_and_clinical_course_of_COVID_19_a_prospective_observational_study.pdfFULLTEXT
- http://dx.doi.org/10.1371/journal.pone.0248918FULLTEXT
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248918&type=printable
- https://lup.lub.lu.se/record/c8524964-64c0-4079-a591-8bdcb1f93fca
- https://doi.org/10.1371/journal.pone.0248918
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