Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

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Andreasson, Louise MunkholmBispebjerg Hospital (author)

Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

Article/chapterEnglish

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LIBRIS-ID:oai:lup.lub.lu.se:c936492a-031d-42d4-8c05-4c2b166c3f04
https://lup.lub.lu.se/record/c936492a-031d-42d4-8c05-4c2b166c3f04URI
https://doi.org/10.1016/j.jaci.2023.11.915DOI

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Language:English
Summary in:English

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Background: Thymic stromal lymphopoietin (TSLP) is released from the airway epithelium in response to various environmental triggers, inducing a type-2 inflammatory response, and is associated with airway inflammation, airway hyperresponsiveness (AHR), and exacerbations. TSLP may also induce AHR via a direct effect on airway smooth muscle and mast cells, independently of type-2 inflammation, although association between airway TSLP and AHR across asthma phenotypes has been described sparsely. Objectives: This study sought to investigate the association between AHR and levels of TSLP in serum, sputum, and bronchoalveolar lavage in patients with asthma with and without type-2 inflammation. Methods: A novel ultrasensitive assay was used to measure levels of TSLP in patients with asthma (serum, n = 182; sputum, n = 81; bronchoalveolar lavage, n = 85) and healthy controls (serum, n = 47). The distribution and association among airway and systemic TSLP, measures of AHR, type-2 inflammation, and severity of disease were assessed. Results: TSLP in sputum was associated with AHR independently of levels of eosinophils and fractional exhaled nitric oxide (ρ = 0.49, P = .005). Serum TSLP was higher in both eosinophil-high and eosinophil-low asthma compared to healthy controls: geometric mean: 1600 fg/mL (95% CI: 1468-1744 fg/mL) and 1294 fg/mL (95% CI: 1167-1435 fg/mL) versus 846 fg/mL (95% CI: 661-1082 fg/mL), but did not correlate with the level of AHR. Increasing age, male sex, and eosinophils in blood were associated with higher levels of TSLP in serum, whereas lung function, inhaled corticosteroid dose, and symptom score were not. Conclusions: The association between TSLP in sputum and AHR to mannitol irrespective of markers of type-2 inflammation further supports a role of TSLP in AHR that is partially independent of eosinophilic inflammation.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Airway hyperresponsiveness
asthma
blood
eosinophils
sputum
TSLP

Added entries (persons, corporate bodies, meetings, titles ...)

Dyhre-Petersen, NannaBispebjerg Hospital (author)
Hvidtfeldt, MortenBispebjerg Hospital (author)
Jørgensen, Gustav ØrtingBispebjerg Hospital (author)
Von Bülow, AnnaBispebjerg Hospital (author)
Klein, Ditte KjærsgaardBispebjerg Hospital (author)
Uller, LenaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Respiratory Immunopharmacology,Lund University Research Groups(Swepub:lu)mphy-lul (author)
Erjefält, JonasLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,DCD transplantation av lungor,Airway Inflammation and Immunology,Lund University Research Groups,DCD transplantation of lungs(Swepub:lu)mphy-jer (author)
Porsbjerg, CelesteBispebjerg Hospital (author)
Sverrild, AsgerBispebjerg Hospital (author)
Bispebjerg HospitalInstitutionen för experimentell medicinsk vetenskap (creator_code:org_t)

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