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Impact of pathogen ...
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Kostin, Alexander I.N.V. Sklifosovsky Research Institute of Emergency Medicine
(author)
Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:c9618d05-845c-42cd-9b99-0782d38e361a
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https://lup.lub.lu.se/record/c9618d05-845c-42cd-9b99-0782d38e361aURI
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https://doi.org/10.1111/vox.13056DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background and objectives: COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma. Materials and methods: A total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction. Results: The methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment. Conclusion: Pathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.
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Lundgren, Maria N.Region Skåne
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Bulanov, Andrey Y.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Ladygina, Elena A.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Chirkova, Karina S.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Gintsburg, Alexander L.Gamaleya Research Institute of Epidemiology and Microbiology
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Logunov, Denis Y.Gamaleya Research Institute of Epidemiology and Microbiology
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Dolzhikova, Inna V.Gamaleya Research Institute of Epidemiology and Microbiology
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Shcheblyakov, Dmitry V.Gamaleya Research Institute of Epidemiology and Microbiology
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Borovkova, Natalia V.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Godkov, Mikhail A.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Bazhenov, Alexey I.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Shustov, Valeriy V.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Bogdanova, Alina S.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Kamalova, Alina R.Pirogov Russian National Research Medical University (RNRMU)
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Ganchin, Vladimir V.Centre of Social Sector Analytical Development, Moscow
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Dombrovskiy, Eugene A.Centre of Social Sector Analytical Development, Moscow
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Volkov, Stanislav E.Lund University,Lunds universitet,Probability and Inference Theory Group,Forskargrupper vid Lunds universitet,Matematisk statistik,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Lund University Research Groups,Mathematical Statistics,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)mats-svk
(author)
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Drozdova, Nataliya E.N.V. Sklifosovsky Research Institute of Emergency Medicine
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Petrikov, Sergey S.N.V. Sklifosovsky Research Institute of Emergency Medicine
(author)
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N.V. Sklifosovsky Research Institute of Emergency MedicineRegion Skåne
(creator_code:org_t)
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In:Vox Sanguinis: Wiley116:6, s. 665-6720042-90071423-0410
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