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Serum sclerostin an...
Serum sclerostin and glucose homeostasis : No association in healthy men. Cross-sectional and prospective data from the EGIR-RISC study
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- Lauterlein, Jens Jacob L. (författare)
- Odense University Hospital
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- Hermann, Pernille (författare)
- Odense University Hospital
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- Konrad, Thomas (författare)
- Goethe University
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- Wolf, Peter (författare)
- Medical University of Vienna
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- Nilsson, Peter (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Sánchez, Rafael Gabriel (författare)
- Carlos III Health Institute
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- Ferrannini, Ele (författare)
- CNR Institute of Clinical Physiology (IFC-CNR)
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- Balkau, Beverley (författare)
- University of Paris-Saclay
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- Højlund, Kurt (författare)
- Odense University Hospital
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- Frost, Morten (författare)
- Odense University Hospital
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Bone. - : Elsevier BV. - 8756-3282. ; 143
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.scienced...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Introduction: Sclerostin, an inhibitor of bone formation, has emerged as a potential negative regulator of glucose homeostasis. We aimed to investigate if serum sclerostin associates with insulin sensitivity, beta cell function, prediabetes or metabolic syndrome in healthy men. Materials and methods: Serum sclerostin was measured in basal and insulin-stimulated samples from 526 men without diabetes from the RISC cohort study. An OGTT was performed at baseline and after 3 years. An IVGTT and a hyperinsulinaemic-euglycaemic clamp were performed at baseline. Insulin sensitivity was estimated by the oral glucose sensitivity index (OGIS) and the M-value relative to insulin levels. Beta cell function was assessed by the acute and total insulin secretion (ISRtot) and by beta cell glucose sensitivity. Results: Serum sclerostin levels correlated positively with age but were similar in individuals with (n = 69) and without (n = 457) prediabetes or the metabolic syndrome. Serum sclerostin was associated with measures of neither insulin sensitivity nor beta cell function at baseline in age-adjusted analyses including all participants. However, baseline serum sclerostin correlated inversely with OGIS at follow-up in men without prediabetes (B: −0.29 (−0.57, −0.01) p = 0.045), and inversely with beta cell glucose sensitivity in men with prediabetes (B: −13.3 (−26.3, −0.2) p = 0.046). Associations between serum sclerostin and 3-year changes in measures of glucose homeostasis were not observed. Acute hyperinsulinemia suppressed serum sclerostin (p = 0.02), and this reduction correlated with OGIS and ISRtot. Conclusions: Overall, serum sclerostin was not associated with prediabetes, insulin sensitivity or insulin secretion in healthy men. The inverse relationship between serum sclerostin and insulin sensitivity at follow-up was weak and likely not of clinical relevance. The ability of insulin to reduce sclerostin, possibly promoting bone formation, needs to be clarified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Bone-glucose interactions
- Insulin secretion
- Insulin sensitivity
- Prediabetes
- Sclerostin
- Wnt/β-catenin/LRP5
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Lauterlein, Jens ...
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Hermann, Pernill ...
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Konrad, Thomas
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Wolf, Peter
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Nilsson, Peter
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Sánchez, Rafael ...
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visa fler...
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Ferrannini, Ele
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Balkau, Beverley
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Højlund, Kurt
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Frost, Morten
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