Search: id:"swepub:oai:lup.lub.lu.se:c9929100-cd93-4e1e-8420-b0002b52127d" >
Intracerebral regio...
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Fu, JingLund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups
(author)
Intracerebral regional distribution of blood flow in response to uterine contractions in growth-restricted human fetuses.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Elsevier BV,2007
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electronicrdacarrier
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LIBRIS-ID:oai:lup.lub.lu.se:c9929100-cd93-4e1e-8420-b0002b52127d
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https://lup.lub.lu.se/record/166938URI
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https://doi.org/10.1016/j.earlhumdev.2007.01.011DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective: To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth -restricted fetuses with and without established brain-sparing flow during basal conditions. Material and methods: 47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Doppler velocimetry in the umbilical artery, MCA and ACA. The MCA-to-ACA pulsatility index (PI) ratio was calculated during basal conditions, contractions and relaxations. Basal brain-sparing flow was defined as an MCA-to-umbilical artery PI ratio of <1.08, de novo brain-sparing flow in the MCA as an MCA PI decrease with I standard deviation during uterine contractions or relaxations compared with basal measurements, and de novo brain-sparing flow in the ACA as an ACA PI decrease with l standard deviation. Non-parametric statistical tests were used with P<0.05 considered significant. Results: MCA and ACA PI were both significantly tower in the brain-sparing flow group (N=8) during basal conditions (P <= 0.01). During the oxytocin challenge test, MCA and ACA PI both decreased in the non-brain -sparing flow group (N=39) (P <= 0.02) but not in the brain -sparing flow group (P >= 0.4). The MCA-to-ACA PI ratio remained unchanged in both groups. de novo brain-sparing flow calculations revealed no preferential flow to any cerebral artery. Conclusion: Cerebral circulatory responses to acute hypoxemia are synchronized in the middle and anterior cerebral arteries without any preferential regional flow distribution.
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Olofsson, PerLund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups(Swepub:lu)obst-pol
(author)
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Urogynekologi och reproduktionsfarmakologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Early Human Development: Elsevier BV83:9, s. 607-6121872-62320378-3782
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