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Clinical Characteri...
Clinical Characterization of Patients Diagnosed with Prostate Cancer and Undergoing Conservative Management : A PIONEER Analysis Based on Big Data
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- Gandaglia, Giorgio (author)
- San Raffaele Hospital
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- Pellegrino, Francesco (author)
- San Raffaele Hospital
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- Golozar, Asieh (author)
- Northeastern University
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- De Meulder, Bertrand (author)
- Association EISBM
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Abbott, Thomas (author)
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Achtman, Ariel (author)
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- Imran Omar, Muhammad (author)
- University of Aberdeen
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Alshammari, Thamir (author)
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- Areia, Carlos (author)
- University of Oxford
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- Asiimwe, Alex (author)
- Bayer Pharma AG
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- Beyer, Katharina (author)
- King's College London
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- Bjartell, Anders (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Campi, Riccardo (author)
- University of Florence
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- Cornford, Philip (author)
- University of Liverpool
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- Falconer, Thomas (author)
- Columbia University
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Feng, Qi (author)
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- Gong, Mengchun (author)
- Southern Medical University
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- Herrera, Ronald (author)
- Bayer Pharma AG
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- Hughes, Nigel (author)
- Janssen Research & Development, Belgium
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Hulsen, Tim (author)
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- Kinnaird, Adam (author)
- University of Alberta
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- Lai, Lana Y.H. (author)
- University of Manchester
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Maresca, Gianluca (author)
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Mottet, Nicolas (author)
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- Oja, Marek (author)
- University of Tartu
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Prinsen, Peter (author)
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Reich, Christian (author)
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- Remmers, Sebastiaan (author)
- Erasmus University Medical Center
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- Roobol, Monique J. (author)
- Erasmus University Medical Center
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Sakalis, Vasileios (author)
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- Seager, Sarah (author)
- IQVIA Inc.
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Smith, Emma J. (author)
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Snijder, Robert (author)
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- Steinbeisser, Carl (author)
- Bayer Pharma AG
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- Thurin, Nicolas H. (author)
- University of Bordeaux
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- Hijazy, Ayman (author)
- Association EISBM
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- van Bochove, Kees (author)
- The Hyve
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- Van den Bergh, Roderick C.N. (author)
- St. Antonius Hospital
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- Van Hemelrijck, Mieke (author)
- King's College London
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- Willemse, Peter Paul (author)
- University Medical Center Utrecht
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- Williams, Andrew E. (author)
- Tufts Medical Center
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- Zounemat Kermani, Nazanin (author)
- Imperial College London
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- Evans-Axelsson, Susan (author)
- Bayer Pharma AG
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- Briganti, Alberto (author)
- San Raffaele Hospital
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- N'Dow, James (author)
- University of Aberdeen
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(creator_code:org_t)
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- 2024
- 2024
- English 9 s.
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In: European Urology. - 0302-2838. ; 85:5, s. 457-465
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the clinical characteristics and long-term outcomes of PCa patients on conservative management by using an international large network of real-world data. Design, setting, and participants: From an initial cohort of >100 000 000 adult individuals included in eight databases evaluated during a virtual study-a-thon hosted by PIONEER, we identified newly diagnosed PCa cases (n = 527 311). Among those, we selected patients who did not receive curative or palliative treatment within 6 mo from diagnosis (n = 123 146). Outcome measurements and statistical analysis: Patient and disease characteristics were reported. The number of patients who experienced the main study outcomes was quantified for each stratum and the overall cohort. Kaplan-Meier analyses were used to estimate the distribution of time to event data. Results and limitations: The most common comorbidities were hypertension (35–73%), obesity (9.2–54%), and type 2 diabetes (11–28%). The rate of PCa-related symptomatic progression ranged between 2.6% and 6.2%. Hospitalization (12–25%) and emergency department visits (10–14%) were common events during the 1st year of follow-up. The probability of being free from both palliative and curative treatments decreased during follow-up. Limitations include a lack of information on patients and disease characteristics and on treatment intent. Conclusions: Our results allow us to better understand the current landscape of patients with PCa managed with conservative treatment. PIONEER offers a unique opportunity to characterize the baseline features and outcomes of PCa patients managed conservatively using real-world data. Patient summary: Up to 25% of men with prostate cancer (PCa) managed conservatively experienced hospitalization and emergency department visits within the 1st year after diagnosis; 6% experienced PCa-related symptoms. The probability of receiving therapies for PCa decreased according to time elapsed after the diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Big data
- Conservative management
- Outcomes
- PIONEER
- Prostate cancer
- Survival
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Gandaglia, Giorg ...
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Pellegrino, Fran ...
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Golozar, Asieh
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De Meulder, Bert ...
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Abbott, Thomas
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Achtman, Ariel
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show more...
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Imran Omar, Muha ...
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Alshammari, Tham ...
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Areia, Carlos
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Asiimwe, Alex
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Beyer, Katharina
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Bjartell, Anders
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Campi, Riccardo
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Cornford, Philip
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Falconer, Thomas
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Feng, Qi
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Gong, Mengchun
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Herrera, Ronald
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Hughes, Nigel
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Hulsen, Tim
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Kinnaird, Adam
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Lai, Lana Y.H.
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Maresca, Gianluc ...
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Mottet, Nicolas
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Oja, Marek
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Prinsen, Peter
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Reich, Christian
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Remmers, Sebasti ...
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Roobol, Monique ...
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Sakalis, Vasilei ...
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Seager, Sarah
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Smith, Emma J.
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Snijder, Robert
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Steinbeisser, Ca ...
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Thurin, Nicolas ...
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Hijazy, Ayman
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van Bochove, Kee ...
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Van den Bergh, R ...
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Van Hemelrijck, ...
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Willemse, Peter ...
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Williams, Andrew ...
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Zounemat Kermani ...
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Evans-Axelsson, ...
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Briganti, Albert ...
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N'Dow, James
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Urology
- By the university
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Lund University