SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19"
 

Search: id:"swepub:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19" > CD137 (4-1BB) costi...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Otano, ItziarSpanish Center for Biomedical Research Network in Oncology (CIBERONC),12 de Octubre University Hospital,Spanish National Cancer Research Center (CNIO),University of Navarra (author)

CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-12-15
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19
  • https://lup.lub.lu.se/record/ca6e18f0-8052-489a-b7cc-7c04728ddb19URI
  • https://doi.org/10.1038/s41467-021-27613-wDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signaling. In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. Cis ligation of CD137 relative to the TCR-CD3 complex results in more intense canonical and non-canonical NF-κB signaling and provides a more robust induction of cell cycle and DNA damage repair gene expression programs. Here we report that the superiority of cis versus trans CD137-costimulation is readily observed in vivo and is relevant for understanding the immunotherapeutic effects of CAR T cells and CD137 agonistic therapies currently undergoing clinical trials, which may provide costimulation either in cis or in trans.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Azpilikueta, ArantzaSpanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • Glez-Vaz, JavierUniversity of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Alvarez, MaiteHealth Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Medina-Echeverz, JoséBavarian Nordic GmbH (author)
  • Cortés-Domínguez, IvanHealth Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Ortiz-de-Solorzano, CarlosSpanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • Ellmark, PeterLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,Alligator Biosciences AB(Swepub:lu)immt-pel (author)
  • Fritzell, SaraAlligator Biosciences AB(Swepub:lu)med-sfz (author)
  • Hernandez-Hoyos, GabrielaAptevo Therapeutics (author)
  • Nelson, Michelle HaseAptevo Therapeutics (author)
  • Ochoa, María CarmenUniversity Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Bolaños, ElixabetSpanish Center for Biomedical Research Network in Oncology (CIBERONC),University Clinic of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • Cuculescu, DoinaSpanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Jaúregui, PatriciaHealth Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Sanchez-Gregorio, SandraHealth Research Institute of Navarra (IDISNA),University of Navarra,University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Etxeberria, IñakiHealth Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Rodriguez-Ruiz, María E.Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra,University Clinic of Navarra (author)
  • Sanmamed, Miguel F.Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University Clinic of Navarra,Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Teijeira, ÁlvaroUniversity of Navarra,Health Research Institute of Navarra (IDISNA),University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Berraondo, PedroSpanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • Melero, IgnacioHealth Research Institute of Navarra (IDISNA),University of Navarra,Spanish National Cancer Research Center (CNIO),University Clinic of Navarra,12 de Octubre University Hospital,Spanish Center for Biomedical Research Network in Oncology (CIBERONC) (author)
  • Spanish Center for Biomedical Research Network in Oncology (CIBERONC)12 de Octubre University Hospital (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC12:12041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view