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  • Walsh, SH (author)

Mutated V-H genes and preferential V(H)3-21 use define new subsets of mantle cell lymphoma

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • 2003-03-13
  • American Society of Hematology,2003

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ca7a4693-8095-4a4f-8102-39c12bdd53da
  • https://lup.lub.lu.se/record/312223URI
  • https://doi.org/10.1182/blood-2002-11-3479DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V-H genes. We also reported restricted use of certain V-H genes. To assess the prognostic impact of these new findings, we performed V-H gene analysis of 110 patients, revealing that 18 (16%) patients had mutated and 92 (84%) patients had unmutated V-H genes. Because the mutation rate was low in the mutated group (2.2%-6.7%), further investigation of the germline V-H gene in T cells from 5 patients with mutated V-H genes was carried out; results showed that the unrearranged V-H gene was identical to the published sequence. These data confirm that the base pair substitutions within the rearranged V-H genes represent hyper-mutations, and indicate germinal center exposure. However, V-H gene mutation status did not correlate with prognosis because there was no difference in clinical outcome between the unmutated and mutated groups. The most frequently used V-H genes were V(H)3-21 (21 patients) and V(H)4-34 (19 patients). A novel finding was that V(H)3-21(+) MCL almost exclusively ex-pressed X light chains and displayed highly restricted use of the V(lambda)3-19 gene. V(H)3-21(+) patients had longer median survival than the remaining patients (53 vs 34 months; P = .03), but they tended to be younger at diagnosis. The combined use Of V(H)3-21/V(lambda)3-19 suggests a possible role for antigen(s) in the pathogenesis of these tumors and indicates that V(H)3-21(+) patients constitute a new MCL entity. (C) 2003 by The American Society of Hematology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Thorselius, M (author)
  • Johnson, AnnaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-ajo (author)
  • Soderberg, O (author)
  • Jerkernan, M (author)
  • Bjorck, E (author)
  • Eriksson, I (author)
  • Thunberg, U (author)
  • Landgren, O (author)
  • Ehinger, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)efor-meh (author)
  • Lofvenberg, E (author)
  • Wallman, K (author)
  • Enblad, G (author)
  • Sander, B (author)
  • Porwit-MacDonald, A (author)
  • Dictor, MichaelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-mdi (author)
  • Olofsson, TorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)efor-tol (author)
  • Sundstrom, C (author)
  • Roos, GunnelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-gro (author)
  • Rosenquist, R (author)
  • TumörmikromiljöSektion I (creator_code:org_t)

Related titles

  • In:Blood: American Society of Hematology101:10, s. 4047-40541528-00200006-4971

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