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Mutated V-H genes a...
Mutated V-H genes and preferential V(H)3-21 use define new subsets of mantle cell lymphoma
- Article/chapterEnglish2003
Publisher, publication year, extent ...
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2003-03-13
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American Society of Hematology,2003
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:ca7a4693-8095-4a4f-8102-39c12bdd53da
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https://lup.lub.lu.se/record/312223URI
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https://doi.org/10.1182/blood-2002-11-3479DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V-H genes. We also reported restricted use of certain V-H genes. To assess the prognostic impact of these new findings, we performed V-H gene analysis of 110 patients, revealing that 18 (16%) patients had mutated and 92 (84%) patients had unmutated V-H genes. Because the mutation rate was low in the mutated group (2.2%-6.7%), further investigation of the germline V-H gene in T cells from 5 patients with mutated V-H genes was carried out; results showed that the unrearranged V-H gene was identical to the published sequence. These data confirm that the base pair substitutions within the rearranged V-H genes represent hyper-mutations, and indicate germinal center exposure. However, V-H gene mutation status did not correlate with prognosis because there was no difference in clinical outcome between the unmutated and mutated groups. The most frequently used V-H genes were V(H)3-21 (21 patients) and V(H)4-34 (19 patients). A novel finding was that V(H)3-21(+) MCL almost exclusively ex-pressed X light chains and displayed highly restricted use of the V(lambda)3-19 gene. V(H)3-21(+) patients had longer median survival than the remaining patients (53 vs 34 months; P = .03), but they tended to be younger at diagnosis. The combined use Of V(H)3-21/V(lambda)3-19 suggests a possible role for antigen(s) in the pathogenesis of these tumors and indicates that V(H)3-21(+) patients constitute a new MCL entity. (C) 2003 by The American Society of Hematology.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Thorselius, M
(author)
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Johnson, AnnaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-ajo
(author)
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Soderberg, O
(author)
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Jerkernan, M
(author)
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Bjorck, E
(author)
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Eriksson, I
(author)
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Thunberg, U
(author)
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Landgren, O
(author)
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Ehinger, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)efor-meh
(author)
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Lofvenberg, E
(author)
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Wallman, K
(author)
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Enblad, G
(author)
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Sander, B
(author)
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Porwit-MacDonald, A
(author)
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Dictor, MichaelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-mdi
(author)
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Olofsson, TorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)efor-tol
(author)
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Sundstrom, C
(author)
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Roos, GunnelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-gro
(author)
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Rosenquist, R
(author)
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TumörmikromiljöSektion I
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology101:10, s. 4047-40541528-00200006-4971
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Walsh, SH
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Thorselius, M
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Johnson, Anna
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Soderberg, O
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Jerkernan, M
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Bjorck, E
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Eriksson, I
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Thunberg, U
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Landgren, O
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Ehinger, Mats
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Lofvenberg, E
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Wallman, K
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Enblad, G
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Sander, B
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Porwit-MacDonald ...
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Dictor, Michael
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Olofsson, Tor
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Sundstrom, C
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Roos, Gunnel
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Rosenquist, R
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