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  • Tenland, ErikLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden (author)

A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier BV,2018
  • 8 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:cb3b7298-bf9b-4398-bcaa-4efa7b01bca2
  • https://lup.lub.lu.se/record/cb3b7298-bf9b-4398-bcaa-4efa7b01bca2URI
  • https://doi.org/10.1016/j.tube.2018.10.008DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139717908URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153519URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agencies|UK Medical Research Council; Swedish Heart-Lung Foundation [20150733]; Alfred Osterlunds Foundation; Royal Physiographic Society of Lund; Swedish Research Council; European Unions Seventh Framework Programme (FP7/2007-2013) [604182]
  • Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium tuberculosis strains complicate treatment and increases mortality rates, making the development of new drugs an urgent priority. In this study we have identified a promising candidate by screening antimicrobial peptides for their capacity to inhibit mycobacterial growth. This non-toxic peptide, NZX, is capable of inhibiting both clinical strains of M. tuberculosis and an MDR strain at therapeutic concentrations. The therapeutic potential of NZX is further supported in vivo where NZX significantly lowered the bacterial load with only five days of treatment, comparable to rifampicin treatment over the same period. NZX possesses intracellular inhibitory capacity and co-localizes with intracellular bacteria in infected murine lungs. In conclusion, the data presented strongly supports the therapeutic potential of NZX in future anti-TB treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Krishnan, NityaImperial College London,Imperial Coll London, England (author)
  • Rönnholm, AnnaLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)med-ar6 (author)
  • Kalsum, SadafLinköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)sadka44 (author)
  • Puthia, ManojLund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)med-mpu (author)
  • Mörgelin, MatthiasKarolinska Institutet,Cobsyx AB, Sweden(Swepub:lu)medk-mmn (author)
  • Davoudi, MinaLund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)derm-mda (author)
  • Otrocka, MagdalenaKarolinska Institute,Karolinska Inst, Sweden (author)
  • Alaridah, NaderLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)med-nua (author)
  • Glegola-Madejska, IzabelaImperial College London,Imperial Coll London, England (author)
  • Sturegård, ErikLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)mmb-est (author)
  • Schmidtchen, ArturLund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)derm-asc (author)
  • Lerm, MariaLinköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)marle69 (author)
  • Robertson, Brian D.Imperial College London,Imperial Coll London, England (author)
  • Godaly, GabrielaLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)mmb-ggo (author)
  • Medicinsk mikrobiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Tuberculosis: Elsevier BV113, s. 231-2381472-97921873-281X

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