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Sökning: onr:"swepub:oai:lup.lub.lu.se:cc86e66a-6d1c-4902-9e21-1db77433bb3a" > Islet Autoimmunity ...

  • Anand, VibhaIBM Thomas J. Watson Research Center (författare)

Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes : Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-06-23
  • American Diabetes Association,2021
  • 8 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:cc86e66a-6d1c-4902-9e21-1db77433bb3a
  • https://lup.lub.lu.se/record/cc86e66a-6d1c-4902-9e21-1db77433bb3aURI
  • https://doi.org/10.2337/dc20-1836DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.RESEARCH DESIGN AND METHODS: For prospective cohorts in Finland, Germany, Sweden, and the U.S., 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes have been followed. Following harmonization, the outcomes were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.RESULTS: In the infant-toddler cohort, 1,413 (8.5%) developed at least one autoantibody confirmed at two or more consecutive visits (seroconversion), 865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to diabetes. The 15-year cumulative incidence of diabetes varied in children with one, two, or three autoantibodies at seroconversion: 45% (95% CI 40-52), 85% (78-90), and 92% (85-97), respectively. Among those with a single autoantibody, status 2 years after seroconversion predicted diabetes risk: 12% (10-25) if reverting to autoantibody negative, 30% (20-40) if retaining a single autoantibody, and 82% (80-95) if developing multiple autoantibodies. HLA-DR-DQ affected the risk of confirmed seroconversion and progression to diabetes in children with stable single-autoantibody status. Their 15-year diabetes incidence for higher- versus lower-risk genotypes was 40% (28-50) vs. 12% (5-38). The rate of progression to diabetes was inversely related to age at development of multiple autoantibodies, ranging from 20% per year to 6% per year in children developing multipositivity in ≤2 years or >7.4 years, respectively.CONCLUSIONS: The number of islet autoantibodies at seroconversion reliably predicts 15-year type 1 diabetes risk. In children retaining a single autoantibody, HLA-DR-DQ genotypes can further refine risk of progression.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, YingIBM Thomas J. Watson Research Center (författare)
  • Liu, BinIBM Thomas J. Watson Research Center (författare)
  • Ghalwash, MohamedAin Shams University,IBM Thomas J. Watson Research Center (författare)
  • Koski, EileenIBM Thomas J. Watson Research Center (författare)
  • Ng, KenneyIBM Thomas J. Watson Research Center (författare)
  • Dunne, Jessica LJuvenile Diabetes Research Foundation (författare)
  • Jönsson, JosefineLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)jo7760jo (författare)
  • Winkler, ChristianeTechnical University of Munich,Helmholtz Zentrum München (författare)
  • Knip, MikaelUniversity of Helsinki,Tampere University Hospital,Helsinki University Central Hospital,Folkhälsan Research Center (författare)
  • Toppari, JormaTurku University Hospital,University of Turku (författare)
  • Ilonen, JormaUniversity of Turku,Turku University Hospital (författare)
  • Killian, Michael BPacific Northwest Research Institute (författare)
  • Frohnert, Brigitte IUniversity of Colorado (författare)
  • Lundgren, MarkusHelmholtz Zentrum München(Swepub:lu)med-mn2 (författare)
  • Ziegler, Anette-GabrieleTechnical University of Munich,Helmholtz Zentrum München (författare)
  • Hagopian, WilliamPacific Northwest Research Institute (författare)
  • Veijola, RiittaUniversity of Oulu,Oulu University Hospital(Swepub:lu)ri3323ve (författare)
  • Rewers, MarianUniversity of Colorado (författare)
  • IBM Thomas J. Watson Research CenterAin Shams University (creator_code:org_t)
  • T1DI Study Group

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association44, s. 2269-22761935-55480149-5992

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