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  • Davies, John RUniversity of Leeds (author)

Development and validation of a melanoma risk score based on pooled data from 16 case-control studies

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015
  • 8 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ce2be338-b0b6-45bf-ac99-82d2779c2c31
  • https://lup.lub.lu.se/record/5142727URI
  • https://doi.org/10.1158/1055-9965.EPI-14-1062DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: We report the development of a cutaneous melanoma risk algorithm based upon seven factors; hair color, skin type, family history, freckling, nevus count, number of large nevi, and history of sunburn, intended to form the basis of a self-assessment Web tool for the general public.METHODS: Predicted odds of melanoma were estimated by analyzing a pooled dataset from 16 case-control studies using logistic random coefficients models. Risk categories were defined based on the distribution of the predicted odds in the controls from these studies. Imputation was used to estimate missing data in the pooled datasets. The 30th, 60th, and 90th centiles were used to distribute individuals into four risk groups for their age, sex, and geographic location. Cross-validation was used to test the robustness of the thresholds for each group by leaving out each study one by one. Performance of the model was assessed in an independent UK case-control study dataset.RESULTS: Cross-validation confirmed the robustness of the threshold estimates. Cases and controls were well discriminated in the independent dataset [area under the curve, 0.75; 95% confidence interval (CI), 0.73-0.78]. Twenty-nine percent of cases were in the highest risk group compared with 7% of controls, and 43% of controls were in the lowest risk group compared with 13% of cases.CONCLUSION: We have identified a composite score representing an estimate of relative risk and successfully validated this score in an independent dataset.IMPACT: This score may be a useful tool to inform members of the public about their melanoma risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chang, Yu-meiUniversity of Leeds (author)
  • Bishop, D TimothyUniversity of Leeds (author)
  • Armstrong, Bruce KUniversity of Sydney (author)
  • Bataille, VeroniqueKing's College London (author)
  • Bergman, WilmaLeiden University Medical Centre (author)
  • Berwick, MarianneUniversity of New Mexico (author)
  • Bracci, Paige MUniversity of California, San Francisco (author)
  • Elwood, J MarkUniversity of Auckland (author)
  • Ernstoff, Marc SDartmouth College (author)
  • Green, AdeleQIMR Berghofer Medical Research Institute (author)
  • Gruis, Nelleke ALeiden University Medical Centre (author)
  • Holly, Elizabeth AUniversity of California, San Francisco (author)
  • Ingvar, ChristianLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-cin (author)
  • Kanetsky, Peter AH. Lee Moffitt Cancer Center & Research Institute (author)
  • Karagas, Margaret RDartmouth College (author)
  • Lee, Tim KBC Cancer Research Centre (author)
  • Le Marchand, LoïcUniversity of Hawaii Cancer Center (author)
  • Mackie, Rona MUniversity of Glasgow (author)
  • Olsson, HåkanLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol (author)
  • Østerlind, AnneNo affiliation available (private) (author)
  • Rebbeck, Timothy RUniversity of Pennsylvania (author)
  • Reich, KristianDermatologikum Hamburg (author)
  • Sasieni, PeterQueen Mary University (author)
  • Siskind, VictorQIMR Berghofer Medical Research Institute (author)
  • Swerdlow, Anthony JInstitute of Cancer Research London (author)
  • Titus, LindaDartmouth College (author)
  • Zens, Michael SDartmouth College (author)
  • Ziegler, AndreasUniversity of Lübeck (author)
  • Gallagher, Richard PBC Cancer Research Centre (author)
  • Barrett, Jennifer HUniversity of Leeds (author)
  • Newton-Bishop, JuliaUniversity of Leeds (author)
  • University of LeedsUniversity of Sydney (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology Biomarkers & Prevention24:5, s. 24-8171538-7755

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