Sökning: WFRF:(Manninen J.)
> (2020-2024) >
In vivo disentangle...
In vivo disentanglement of diffusion frequency-dependence, tensor shape, and relaxation using multidimensional MRI
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- Johnson, Jessica T.E. (författare)
- National Institute on Aging, United States
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- Irfanoglu, M. Okan (författare)
- National Institutes of Health, United States
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- Manninen, Eppu (författare)
- National Institute on Aging, United States
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- Ross, Thomas J. (författare)
- National Institute on Drug Abuse (NIDA)
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- Yang, Yihong (författare)
- National Institute on Drug Abuse (NIDA)
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- Laun, Frederik B. (författare)
- University Hospital Erlangen
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- Martin, Jan (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Topgaard, Daniel (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Benjamini, Dan (författare)
- National Institute on Aging, United States
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Human Brain Mapping. - 1065-9471. ; 45:7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Diffusion MRI with free gradient waveforms, combined with simultaneous relaxation encoding, referred to as multidimensional MRI (MD-MRI), offers microstructural specificity in complex biological tissue. This approach delivers intravoxel information about the microstructure, local chemical composition, and importantly, how these properties are coupled within heterogeneous tissue containing multiple microenvironments. Recent theoretical advances incorporated diffusion time dependency and integrated MD-MRI with concepts from oscillating gradients. This framework probes the diffusion frequency, (Formula presented.), in addition to the diffusion tensor, (Formula presented.), and relaxation, (Formula presented.), (Formula presented.), correlations. A (Formula presented.) clinical imaging protocol was then introduced, with limited brain coverage and 3 mm3 voxel size, which hinder brain segmentation and future cohort studies. In this study, we introduce an efficient, sparse in vivo MD-MRI acquisition protocol providing whole brain coverage at 2 mm3 voxel size. We demonstrate its feasibility and robustness using a well-defined phantom and repeated scans of five healthy individuals. Additionally, we test different denoising strategies to address the sparse nature of this protocol, and show that efficient MD-MRI encoding design demands a nuanced denoising approach. The MD-MRI framework provides rich information that allows resolving the diffusion frequency dependence into intravoxel components based on their (Formula presented.) distribution, enabling the creation of microstructure-specific maps in the human brain. Our results encourage the broader adoption and use of this new imaging approach for characterizing healthy and pathological tissues.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- denoising
- diffusion tensor distribution
- diffusion time dependency
- diffusion-relaxation
- human brain
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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