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Identification of t...
Identification of ten loci associated with height highlights new biological pathways in human growth
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Lettre, Guillaume (author)
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Jackson, Anne U. (author)
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Gieger, Christian (author)
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show more...
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Schumacher, Fredrick R. (author)
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Berndt, Sonja I. (author)
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Sanna, Serena (author)
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Eyheramendy, Susana (author)
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Voight, Benjamin F. (author)
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Butler, Johannah L. (author)
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Guiducci, Candace (author)
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Illig, Thomas (author)
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Hackett, Rachel (author)
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Heid, Iris M. (author)
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Jacobs, Kevin B. (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Uda, Manuela (author)
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Boehnke, Michael (author)
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Chanock, Stephen J. (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Hu, Frank B. (author)
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Isomaa, Bo (author)
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Kraft, Peter (author)
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Peltonen, Leena (author)
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Salomaa, Veikko (author)
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Schlessinger, David (author)
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Hunter, David J. (author)
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Hayes, Richard B. (author)
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Abecasis, Goncalo R. (author)
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Wichmann, H-Erich (author)
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Mohlke, Karen L. (author)
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Hirschhorn, Joel N. (author)
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(creator_code:org_t)
- 2008-04-06
- 2008
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 584-591
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http://dx.doi.org/10...
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https://europepmc.or...
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Abstract
Subject headings
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- Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in 410,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for similar to 2% of the population variation in height. Individuals with <= 8 height-increasing alleles and >= 16 height-increasing alleles differ in height by similar to 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Lettre, Guillaum ...
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Jackson, Anne U.
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Gieger, Christia ...
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Schumacher, Fred ...
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Berndt, Sonja I.
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Sanna, Serena
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show more...
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Eyheramendy, Sus ...
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Voight, Benjamin ...
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Butler, Johannah ...
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Guiducci, Candac ...
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Illig, Thomas
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Hackett, Rachel
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Heid, Iris M.
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Jacobs, Kevin B.
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Lyssenko, Valeri ...
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Uda, Manuela
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Boehnke, Michael
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Chanock, Stephen ...
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Groop, Leif
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Hu, Frank B.
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Isomaa, Bo
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Kraft, Peter
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Peltonen, Leena
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Salomaa, Veikko
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Schlessinger, Da ...
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Hunter, David J.
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Hayes, Richard B ...
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Abecasis, Goncal ...
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Wichmann, H-Eric ...
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Mohlke, Karen L.
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Hirschhorn, Joel ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Nature Genetics
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Lund University