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  • Mortensen, Camilla BekkerLund University,Lunds universitet,Hälsofrämjande komplexa interventioner,Forskargrupper vid Lunds universitet,Health-promoting Complex Interventions,Lund University Research Groups,Zealand University Hospital,CRIC - Collaboration for Research in Intensive Care (author)

Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:cecbe602-064f-45c2-89df-afe4c2f1ac17
  • https://lup.lub.lu.se/record/cecbe602-064f-45c2-89df-afe4c2f1ac17URI
  • https://doi.org/10.1007/s00134-023-07282-7DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level questionnaire (EQ-5D-5L) index values and EQ visual analogue scale (EQ VAS) (deceased patients were assigned the numeric value zero). Outcomes were analysed using logistic and linear regressions with bootstrapping and G-computation, all with adjustment for the stratification variables (site and delirium motor subtype) and multiple imputations for missing HRQoL values. Results: At 1-year follow-up, we obtained vital status for 96.2% and HRQoL data for 83.3% of the 1000 randomised patients. One-year mortality was 224/501 (44.7%) in the haloperidol group versus 251/486 (51.6%) in the placebo group, with an adjusted absolute risk difference of − 6.4%-points (95% confidence interval [CI] − 12.8%-points to − 0.2%-points; P = 0.045). These results were largely consistent across the secondary analyses. For HRQoL, the adjusted mean differences were 0.04 (95% CI − 0.03 to 0.11; P = 0.091) for EQ-5D-5L-5L index values, and 3.3 (95% CI − 9.3 to 17.5; P = 0.142) for EQ VAS. Conclusions: In acutely admitted adult ICU patients with delirium, haloperidol treatment reduced mortality at 1-year follow-up, but did not statistically significantly improve HRQoL.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Andersen-Ranberg, Nina ChristineZealand University Hospital (author)
  • Poulsen, Lone MusaeusZealand University Hospital (author)
  • Granholm, AndersCopenhagen University Hospital (author)
  • Rasmussen, Bodil SteenAalborg University Hospital,Aalborg University (author)
  • Kjær, Maj Brit NørregaardCopenhagen University Hospital (author)
  • Lange, TheisUniversity of Copenhagen,Copenhagen University Hospital (author)
  • Ebdrup, Bjørn H.University of Copenhagen (author)
  • Collet, Marie OxenbøllCopenhagen University Hospital (author)
  • Andreasen, Anne SofieCopenhagen University Hospital (author)
  • Bestle, Morten HeibergUniversity of Copenhagen,Copenhagen University Hospital (author)
  • Uslu, BülentZealand University Hospital (author)
  • Pedersen, Helle ScharlingNykøbing Falster Hospital,Zealand University Hospital (author)
  • Nielsen, Louise GramstrupOdense University Hospital (author)
  • Hästbacka, JohannaTampere University Hospital,Helsinki University Central Hospital (author)
  • Jensen, Troels Bek (author)
  • Damgaard, Kjeld (author)
  • Sommer, TrineOdense University Hospital (author)
  • Morgen, MatthewUniversity Hospital of Wales (author)
  • Dey, Nilanjan (author)
  • Citerio, GuiseppeUniversity of Milano-Bicocca (author)
  • Estrup, StineCopenhagen University Hospital (author)
  • Egerod, IngridCopenhagen University Hospital (author)
  • Samuelson, KarinLund University,Lunds universitet,Hälsa i ett tvärvetenskapligt perspektiv,Forskargrupper vid Lunds universitet,Integrative Health Research,Lund University Research Groups(Swepub:lu)omv-ksa (author)
  • Perner, AndersCopenhagen University Hospital,University of Copenhagen (author)
  • Mathiesen, OleUniversity of Copenhagen,Zealand University Hospital (author)
  • Hälsofrämjande komplexa interventionerForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Intensive Care Medicine50:1, s. 103-1130342-4642

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