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Long-term outcomes ...
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Mortensen, Camilla BekkerLund University,Lunds universitet,Hälsofrämjande komplexa interventioner,Forskargrupper vid Lunds universitet,Health-promoting Complex Interventions,Lund University Research Groups,Zealand University Hospital,CRIC - Collaboration for Research in Intensive Care
(author)
Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium
- Article/chapterEnglish2024
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LIBRIS-ID:oai:lup.lub.lu.se:cecbe602-064f-45c2-89df-afe4c2f1ac17
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https://lup.lub.lu.se/record/cecbe602-064f-45c2-89df-afe4c2f1ac17URI
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https://doi.org/10.1007/s00134-023-07282-7DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level questionnaire (EQ-5D-5L) index values and EQ visual analogue scale (EQ VAS) (deceased patients were assigned the numeric value zero). Outcomes were analysed using logistic and linear regressions with bootstrapping and G-computation, all with adjustment for the stratification variables (site and delirium motor subtype) and multiple imputations for missing HRQoL values. Results: At 1-year follow-up, we obtained vital status for 96.2% and HRQoL data for 83.3% of the 1000 randomised patients. One-year mortality was 224/501 (44.7%) in the haloperidol group versus 251/486 (51.6%) in the placebo group, with an adjusted absolute risk difference of − 6.4%-points (95% confidence interval [CI] − 12.8%-points to − 0.2%-points; P = 0.045). These results were largely consistent across the secondary analyses. For HRQoL, the adjusted mean differences were 0.04 (95% CI − 0.03 to 0.11; P = 0.091) for EQ-5D-5L-5L index values, and 3.3 (95% CI − 9.3 to 17.5; P = 0.142) for EQ VAS. Conclusions: In acutely admitted adult ICU patients with delirium, haloperidol treatment reduced mortality at 1-year follow-up, but did not statistically significantly improve HRQoL.
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Andersen-Ranberg, Nina ChristineZealand University Hospital
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Poulsen, Lone MusaeusZealand University Hospital
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Granholm, AndersCopenhagen University Hospital
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Rasmussen, Bodil SteenAalborg University Hospital,Aalborg University
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Kjær, Maj Brit NørregaardCopenhagen University Hospital
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Lange, TheisUniversity of Copenhagen,Copenhagen University Hospital
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Ebdrup, Bjørn H.University of Copenhagen
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Collet, Marie OxenbøllCopenhagen University Hospital
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Andreasen, Anne SofieCopenhagen University Hospital
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Bestle, Morten HeibergUniversity of Copenhagen,Copenhagen University Hospital
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Uslu, BülentZealand University Hospital
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Pedersen, Helle ScharlingNykøbing Falster Hospital,Zealand University Hospital
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Nielsen, Louise GramstrupOdense University Hospital
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Hästbacka, JohannaTampere University Hospital,Helsinki University Central Hospital
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Jensen, Troels Bek
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Damgaard, Kjeld
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Sommer, TrineOdense University Hospital
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Morgen, MatthewUniversity Hospital of Wales
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Dey, Nilanjan
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Citerio, GuiseppeUniversity of Milano-Bicocca
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Estrup, StineCopenhagen University Hospital
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Egerod, IngridCopenhagen University Hospital
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Samuelson, KarinLund University,Lunds universitet,Hälsa i ett tvärvetenskapligt perspektiv,Forskargrupper vid Lunds universitet,Integrative Health Research,Lund University Research Groups(Swepub:lu)omv-ksa
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Perner, AndersCopenhagen University Hospital,University of Copenhagen
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Mathiesen, OleUniversity of Copenhagen,Zealand University Hospital
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Hälsofrämjande komplexa interventionerForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Intensive Care Medicine50:1, s. 103-1130342-4642
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Mortensen, Camil ...
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Andersen-Ranberg ...
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Poulsen, Lone Mu ...
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Granholm, Anders
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Rasmussen, Bodil ...
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Kjær, Maj Brit N ...
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Lange, Theis
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Ebdrup, Bjørn H.
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Collet, Marie Ox ...
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Bestle, Morten H ...
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Uslu, Bülent
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Pedersen, Helle ...
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Jensen, Troels B ...
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Damgaard, Kjeld
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Sommer, Trine
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Morgen, Matthew
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Dey, Nilanjan
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Citerio, Guisepp ...
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Egerod, Ingrid
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