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Broadening risk pro...
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Therkildsen, ChristinaCopenhagen University Hospital
(författare)
Broadening risk profile in familial colorectal cancer type X; Increased risk for five cancer types in the national Danish cohort
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-04-22
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Springer Science and Business Media LLC,2020
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:cf95261f-7ab3-481c-b23f-af44beb2f009
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https://lup.lub.lu.se/record/cf95261f-7ab3-481c-b23f-af44beb2f009URI
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https://doi.org/10.1186/s12885-020-06859-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: Familial colorectal cancer type X (FCCTX) is a phenotypically defined subset of hereditary colorectal cancer with unknown and potentially heterogeneous genetic aetiology. FCCTX has been characterized as a colorectal cancer-specific syndrome, which we herein challenge by estimating the risk for extra-colorectal cancer in the Danish FCCTX cohort. Methods: Through the national hereditary non-polyposis colorectal cancer (HNPCC) register, 213 families fulfilling the Amsterdam I criteria and showing retained mismatch repair (MMR) function were identified. In here, sex and age-specific incidence rate ratios (IRR) were calculated for 30 extra-colorectal cancer types in comparison with the general Danish population. Results: In total, 494 extra-colorectal cancers developed with significantly increased risks for cancers of the urinary tract, breast, stomach, pancreas, and eye tumours. The age groups at increased risks were 30-49 years for gastric cancer, 30-69 years for female breast cancer, 50-69 years for ocular melanoma and above age 70 for pancreatic cancer and urothelial cancer. Conclusions: Danish FCCTX families show an increased risk of several extra-colorectal cancer types. This observation may indicate unidentified disease-predisposing genetic variants in this phenotypically defined subset of hereditary colorectal cancer and calls for awareness during genetic counselling and follow-up.
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Rasmussen, MariaCopenhagen University Hospital
(författare)
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Smith-Hansen, LarsCopenhagen University Hospital
(författare)
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Kallemose, ThomasCopenhagen University Hospital
(författare)
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Lindberg, Lars JoachimUniversity of Copenhagen,Copenhagen University Hospital
(författare)
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Nilbert, MefLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Danish Cancer Society,Copenhagen University Hospital(Swepub:lu)onk-mni
(författare)
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Copenhagen University HospitalUniversity of Copenhagen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Cancer: Springer Science and Business Media LLC20:11471-2407
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