Search: (WFRF:(Chirlaque Mariá Dolores)) srt2:(2015-2019) >
Vasectomy and prost...
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Byrne, Karl SmithUniversity of Oxford
(author)
Vasectomy and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Article/chapterEnglish2017
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LIBRIS-ID:oai:lup.lub.lu.se:cfb1cd77-b582-4ff9-a4bd-6dea4c75f4a6
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https://lup.lub.lu.se/record/cfb1cd77-b582-4ff9-a4bd-6dea4c75f4a6URI
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https://doi.org/10.1200/JCO.2016.70.0062DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84, 753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. Results During an average follow-up of 15.4 years, 4, 377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade (P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). Conclusion These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not.
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Castaño, Jose MariaMurcia Regional Health Council
(author)
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Chirlaque, Maria DoloresImib Instituto Murciano De Investigación Biosanitaria,Murcia Regional Health Council
(author)
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Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Memorial Sloan-Kettering Cancer Center,University of Oxford(Swepub:lu)klke-hli
(author)
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Agudo, AntonioCatalan Institute of Oncology
(author)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05
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Rodríguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP)
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Boeing, HeinerGerman Institute of Human Nutrition
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Kaaks, RudolfGerman Cancer Research Centre
(author)
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Khaw, Kay TeeUniversity of Cambridge
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Larrañaga, NereaCIBER Epidemiology and Public Health (CIBERESP)
(author)
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Navarro, CarmenCIBER Epidemiology and Public Health (CIBERESP)
(author)
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Olsen, Anja
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Overvad, Kim
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Perez-Cornago, Aurora
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Rohrmann, Sabine
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Sánchez, Maria José
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Tjønneland, Anne
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Tsilidis, Konstantinos K.
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Johansson, Mattias
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Riboli, Elio
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Key, Timothy J.
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Travis, Ruth C.
(author)
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University of OxfordMurcia Regional Health Council
(creator_code:org_t)
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In:Journal of Clinical Oncology35:12, s. 1297-13030732-183X
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Lilja, Hans
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Boeing, Heiner
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Kaaks, Rudolf
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Larrañaga, Nerea
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Navarro, Carmen
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Olsen, Anja
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Overvad, Kim
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Perez-Cornago, A ...
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Rohrmann, Sabine
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Sánchez, Maria J ...
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Tjønneland, Anne
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Tsilidis, Konsta ...
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Johansson, Matti ...
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Riboli, Elio
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Key, Timothy J.
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