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  • Funkquist, Anders,1977-Halmstad County Hospital,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden (author)

Low CSF/serum ratio of free T4 is associated with decreased quality of life in mild hypothyroidism – A pilot study : CSF/s-T4 associated with QoL in hypothyroidism

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Netherlands :Elsevier BV,2020

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  • LIBRIS-ID:oai:lup.lub.lu.se:d072e5a5-513c-49fb-b462-29521970c90c
  • https://lup.lub.lu.se/record/d072e5a5-513c-49fb-b462-29521970c90cURI
  • https://doi.org/10.1016/j.jcte.2020.100218DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88954URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:232154116URI
  • https://gup.ub.gu.se/publication/291708URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agency:Sodra Sjukvardsregionen and Region Hallands forskningsfond 
  • Background & Objective: Patients with mild hypothyroidism often are depressed and have impaired quality of life despite serum free-T4 and T3 within reference values. Therefore, we investigated whether their symptoms were dependent on the concentrations of free -T4 and T3 in the circulation and cerebrospinal fluid (CSF). Methods: Twenty-five newly diagnosed, untreated hypothyroid subjects and as many age- and sex-matched healthy controls were investigated. Blood and CSF sampling was performed in the morning after an overnight fast. Quality of life (QoL) was assessed by a Likert scale. In the hypothyroid subjects, the MADRS rating scale was also used to evaluate symptoms of depression. Furthermore, the results obtained by the questionnaires were related to serum and CSF levels of free- T4 and T3 as well as the ratios between them in CSF and in serum. Results: Self-reported health was considerably lower in hypothyroid subjects. MADRS was considerably higher than the normal range for healthy individuals. Low CSF/serum free-T4 ratio was correlated with an increased depressed state according to MADRS (p < 0.01), and in addition, CSF/serum free-T4 ratio correlated positively with the self-reported general health Likert scale (p < 0.05). Concentrations of TSH, or free-T3 in serum or CSF, were not associated with an increased depressed state or self-reported general health. Conclusions: Low CSF/serum ratio of free-T4 was correlated with impaired general health and mood, in contrast to serum measurements not showing any correlations. These findings might partly explain why some patients with hypothyroidism suffer from mental symptoms, despite adequate serum levels of free-T4. However, the findings need to be confirmed in further and larger studies.

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  • Bengtsson, AndersKarolinska Institute,Halmstad County Hospital,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden; Dpt. of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (author)
  • Johansson, P. M.Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Dpt. of Clinical Sciences Helsingborg, Lund University, Sweden; Dpt. of Internal Medicine at Institute of Medicine, Sahlgrenska Academy, University of Göteborg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjperq (author)
  • Svensson, JohanGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xsjohc (author)
  • Bjellerup, PerDpt. of Laboratory Medicine, Central Hospital Västmanland, Västerås, Sweden (author)
  • Blennow, KajGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Wandt, BirgerÖrebro University,Dpt. of Research and Education, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden (author)
  • Sjöberg, StefanKarolinska Institutet,Karolinska Institute,Halmstad County Hospital,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden; Dpt. of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (author)
  • Halmstad County HospitalDpt. of Medicine, Halland Central Hospital, Halmstad, Sweden (creator_code:org_t)

Related titles

  • In:Journal of Clinical and Translational EndocrinologyNetherlands : Elsevier BV192214-6237

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