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Dietary methyl-grou...
Dietary methyl-group donor intake and breast cancer risk in the european prospective investigation into cancer and nutrition (EPIC)
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- Van Puyvelde, Heleen (author)
- International Agency for Research on Cancer, World Health Organization,Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France; Research Foundation—Flanders (FWO), Brussels, Belgium
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- Papadimitriou, Nikos (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Clasen, Joanna (author)
- St Mary's University, Twickenham,Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Hospital, London, United Kingdom
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- Muller, David (author)
- St Mary's University, Twickenham,Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Hospital, London, United Kingdom
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- Biessy, Carine (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Halkjær, Jytte (author)
- Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
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- Overvad, Kim (author)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
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- Tjønneland, Anne (author)
- Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark,University of Copenhagen
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- Fortner, Renée T. (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany,University of Potsdam
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- Chiodini, Paolo (author)
- Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
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- Masala, Giovanna (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, Firenze, Italy
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- Pala, Valeria (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian, 1, Milano, Italy
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- Sacerdote, Carlotta (author)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Bakker, Marije F. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Agudo, Antonio (author)
- Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Institut Català d’Oncologa, L’Hospitalet de Llobregat, Barcelona, Spain,Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Ardanaz, Eva (author)
- Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain,Health Research Institute of Navarra (IDISNA)
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- López, María Dolores Chirlaque (author)
- CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain,University of Murcia
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- Sánchez, Maria Jose (author)
- CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs., Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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- Gylling, Björn, 1978- (author)
- Umeå universitet,Umeå University,Patologi
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- Karlsson, Therese, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Surgery, Skåne University Hospital Malmö, Lund University, Bröstmottagningen, Malmö, Sweden
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- Schmidt, Julie A. (author)
- University of Oxford
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- Nicolas, Geneviève (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Casagrande, Corinne (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization,Office of the Director, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Heath, Alicia K. (author)
- St Mary's University, Twickenham,Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Hospital, London, United Kingdom
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- Godderis, Lode (author)
- Catholic University of Leuven,Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium; IDEWE (Externe dienst voor Preventie en Bescherming op het Werk), Heverlee, Belgium
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- Van Herck, Koen (author)
- Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
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- De Bacquer, Dirk (author)
- Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, Lyon, France
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Halkjaeer, J. (author)
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(creator_code:org_t)
- 2021-05-28
- 2021
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 13:6
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Subject headings
Close
- (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre-and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Betaine
- Breast cancer
- Choline
- EPIC
- Folate
- Methionine
- Betaine
Publication and Content Type
- art (subject category)
- ref (subject category)
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Nutrients
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- By the author/editor
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Van Puyvelde, He ...
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Papadimitriou, N ...
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Clasen, Joanna
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Muller, David
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Biessy, Carine
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Ferrari, Pietro
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show more...
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Halkjær, Jytte
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Overvad, Kim
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Tjønneland, Anne
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Fortner, Renée T ...
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Katzke, Verena
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Schulze, Matthia ...
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Chiodini, Paolo
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Masala, Giovanna
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Pala, Valeria
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Sacerdote, Carlo ...
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Tumino, Rosario
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Bakker, Marije F ...
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Agudo, Antonio
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Ardanaz, Eva
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López, María Dol ...
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Sánchez, Maria J ...
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Ericson, Ulrika
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Gylling, Björn, ...
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Karlsson, Theres ...
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Manjer, Jonas
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Schmidt, Julie A ...
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Nicolas, Geneviè ...
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Casagrande, Cori ...
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Weiderpass, Elis ...
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Heath, Alicia K.
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Godderis, Lode
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Van Herck, Koen
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De Bacquer, Dirk
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Gunter, Marc J.
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Huybrechts, Inge
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Halkjaeer, J.
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and Clinical Medicin ...
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Nutrients
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Lund University
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University of Gothenburg
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Umeå University