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  • Beske, Rasmus PaulinCopenhagen University Hospital (author)

MicroRNA-9-3p : a novel predictor of neurological outcome after cardiac arrest

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-13
  • Oxford University Press (OUP),2022
  • 8 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:d12862ea-6a43-4b3b-aff8-90c3ed65541d
  • https://lup.lub.lu.se/record/d12862ea-6a43-4b3b-aff8-90c3ed65541dURI
  • https://doi.org/10.1093/ehjacc/zuac066DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h. There were no significant differences in age, gender, and pre-hospital data, including lactate level at admission, between miR-9-3p level quartiles. miR-9-3p levels changed markedly following OHCA with a peak at 48 h. Median miR-9-3p levels between TTM 33°C vs. 36°C were not different at any of the four time points. Elevated miR-9-3p levels at 48 h were strongly associated with an unfavourable neurological outcome [OR: 2.21, 95% confidence interval (CI): 1.64-3.15, P < 0.0001). MiR-9-3p was inferior to neuron-specific enolase in predicting functional neurological outcome [area under the curve: 0.79 (95% CI: 0.71-0.87) vs. 0.91 (95% CI: 0.85-0.97)]. Conclusion: MiR-9-3p is strongly associated with neurological outcome following OHCA, and the levels of miR-9-3p are peaking 48 hours following cardiac arrest.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bache, SørenCopenhagen University Hospital (author)
  • Meyer, Martin Abild StengaardCopenhagen University Hospital (author)
  • Kjærgaard, JesperCopenhagen University Hospital (author)
  • Bro-Jeppesen, JohnAarhus University Hospital (author)
  • Obling, LaustCopenhagen University Hospital (author)
  • Olsen, Markus HarboeCopenhagen University Hospital (author)
  • Rossing, MariaCopenhagen University Hospital,University of Copenhagen (author)
  • Nielsen, Finn CiliusCopenhagen University Hospital (author)
  • Møller, KirstenCopenhagen University Hospital,University of Copenhagen (author)
  • Nielsen, NiklasLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups(Swepub:lu)med-nni (author)
  • Hassager, ChristianCopenhagen University Hospital (author)
  • Copenhagen University HospitalAarhus University Hospital (creator_code:org_t)

Related titles

  • In:European Heart Journal: Acute Cardiovascular Care: Oxford University Press (OUP)11:8, s. 609-6162048-87262048-8734

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