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MicroRNA-9-3p : a n...
MicroRNA-9-3p : a novel predictor of neurological outcome after cardiac arrest
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- Beske, Rasmus Paulin (författare)
- Copenhagen University Hospital
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- Bache, Søren (författare)
- Copenhagen University Hospital
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- Meyer, Martin Abild Stengaard (författare)
- Copenhagen University Hospital
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- Kjærgaard, Jesper (författare)
- Copenhagen University Hospital
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- Bro-Jeppesen, John (författare)
- Aarhus University Hospital
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- Obling, Laust (författare)
- Copenhagen University Hospital
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- Olsen, Markus Harboe (författare)
- Copenhagen University Hospital
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- Rossing, Maria (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Nielsen, Finn Cilius (författare)
- Copenhagen University Hospital
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- Møller, Kirsten (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups
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- Hassager, Christian (författare)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2022-06-13
- 2022
- Engelska 8 s.
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Ingår i: European Heart Journal: Acute Cardiovascular Care. - : Oxford University Press (OUP). - 2048-8726 .- 2048-8734. ; 11:8, s. 609-616
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h. There were no significant differences in age, gender, and pre-hospital data, including lactate level at admission, between miR-9-3p level quartiles. miR-9-3p levels changed markedly following OHCA with a peak at 48 h. Median miR-9-3p levels between TTM 33°C vs. 36°C were not different at any of the four time points. Elevated miR-9-3p levels at 48 h were strongly associated with an unfavourable neurological outcome [OR: 2.21, 95% confidence interval (CI): 1.64-3.15, P < 0.0001). MiR-9-3p was inferior to neuron-specific enolase in predicting functional neurological outcome [area under the curve: 0.79 (95% CI: 0.71-0.87) vs. 0.91 (95% CI: 0.85-0.97)]. Conclusion: MiR-9-3p is strongly associated with neurological outcome following OHCA, and the levels of miR-9-3p are peaking 48 hours following cardiac arrest.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiac arrest
- Microrna
- Mir-9-3p
- Neurologic outcome
- Out-of-hospital cardiac arrest
- Prognostication
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- art (ämneskategori)
- ref (ämneskategori)
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Beske, Rasmus Pa ...
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Bache, Søren
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Meyer, Martin Ab ...
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Kjærgaard, Jespe ...
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Bro-Jeppesen, Jo ...
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Obling, Laust
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Olsen, Markus Ha ...
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Rossing, Maria
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Nielsen, Finn Ci ...
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Møller, Kirsten
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Nielsen, Niklas
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Hassager, Christ ...
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