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Clinical Conditions “Suggestive of Progressive Supranuclear Palsy”—Diagnostic Performance
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- Grimm, Max Joseph (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Technical University of Munich
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- Respondek, Gesine (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Hannover Medical School
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- Stamelou, Maria (författare)
- National and Kapodistrian University of Athens,Philipp University of Marburg
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- Arzberger, Thomas (författare)
- World Orthopaedic Concern,University Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Ferguson, Leslie (författare)
- Royal University Hospital, Saskatoon
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- Gelpi, Ellen (författare)
- University of Barcelona,Medical University of Vienna
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- Giese, Armin (författare)
- World Orthopaedic Concern
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- Grossman, Murray (författare)
- University of Pennsylvania
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- Irwin, David J. (författare)
- University of Pennsylvania
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- Pantelyat, Alexander (författare)
- Johns Hopkins University
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- Rajput, Alex (författare)
- Royal University Hospital, Saskatoon
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- Roeber, Sigrun (författare)
- World Orthopaedic Concern
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- van Swieten, John C. (författare)
- Erasmus University Medical Center
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- Troakes, Claire (författare)
- King's College London
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- Meissner, Wassilios G. (författare)
- Groupe Hospitalier Pellegrin,University of Bordeaux,University of Otago
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- Nilsson, Christer (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Piot, Ines (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Technical University of Munich
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- Compta, Yaroslau (författare)
- University of Barcelona,Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Rowe, James B. (författare)
- University of Cambridge
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- Höglinger, Günter U. (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Hannover Medical School,Technical University of Munich
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(creator_code:org_t)
- 2020-09-11
- 2020
- Engelska 13 s.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 35:12, s. 2301-2313
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The Movement Disorder Society diagnostic criteria for progressive supranuclear palsy introduced the diagnostic certainty level “suggestive of progressive supranuclear palsy” for clinical conditions with subtle signs, suggestive of the disease. This category aims at the early identification of patients, in whom the diagnosis may be confirmed as the disease evolves. Objective: To assess the diagnostic performance of the defined clinical conditions suggestive of progressive supranuclear palsy in an autopsy-confirmed cohort. Methods: Diagnostic performance of the criteria was analyzed based on retrospective clinical data of 204 autopsy-confirmed patients with progressive supranuclear palsy and 216 patients with other neurological diseases. Results: The conditions suggestive of progressive supranuclear palsy strongly increased the sensitivity compared to the National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy criteria. Within the first year after symptom onset, 40% of patients with definite progressive supranuclear palsy fulfilled criteria for suggestive of progressive supranuclear palsy. Two-thirds of patients suggestive of progressive supranuclear palsy evolved into probable progressive supranuclear palsy after an average of 3.6 years. Application of the criteria for suggestive of progressive supranuclear palsy reduced the average time to diagnosis from 3.8 to 2.2 years. Conclusions: Clinical conditions suggestive of progressive supranuclear palsy allow earlier identification of patients likely to evolve into clinically possible or probable progressive supranuclear and to have underlying progressive supranuclear palsy pathology. Further work needs to establish the specificity and positive predictive value of this category in real-life clinical settings, and to develop specific biomarkers that enhance their diagnostic accuracy in early disease stages.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- autopsy
- clinical diagnostic criteria
- early diagnosis
- neuropathology
- progressive supranuclear palsy
- suggestive
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- ref (ämneskategori)
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Grimm, Max Josep ...
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Respondek, Gesin ...
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Stamelou, Maria
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Arzberger, Thoma ...
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Ferguson, Leslie
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Gelpi, Ellen
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Giese, Armin
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Grossman, Murray
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Irwin, David J.
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Pantelyat, Alexa ...
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Rajput, Alex
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Roeber, Sigrun
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van Swieten, Joh ...
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Troakes, Claire
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Meissner, Wassil ...
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Nilsson, Christe ...
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Piot, Ines
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Compta, Yaroslau
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Rowe, James B.
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Höglinger, Günte ...
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