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Decreased systolic ...
Decreased systolic blood pressure is associated with increased risk of all-cause mortality in patients with type 2 diabetes and renal impairment : A nationwide longitudinal observational study of 27,732 patients based on the Swedish National Diabetes Register
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- Svensson, Maria K. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Afghahi, Henri (author)
- Skaraborg Hosp, Dept Nephrol, Skovde, Sweden.
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- Franzen, Stefan (author)
- Ctr Registers Vastra Gotaland, Gothenburg, Sweden.
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- Björk, Staffan (author)
- Ctr Registers Vastra Gotaland, Gothenburg, Sweden.
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- Gudbjörnsdottir, Soffia (author)
- Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
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- Svensson, Ann-Marie (author)
- Ctr Registers Vastra Gotaland, Gothenburg, Sweden.
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- Eliasson, Björn (author)
- Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
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(creator_code:org_t)
- 2017-02-01
- 2017
- English.
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In: Diabetes & Vascular Disease Research. - : SAGE PUBLICATIONS LTD. - 1479-1641 .- 1752-8984. ; 14:3, s. 226-235
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Abstract
Subject headings
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- Background: Previous studies have shown a U-shaped relationship between systolic blood pressure and risk of all-cause of mortality in patients with type 2 diabetes and renal impairment.Aims: To evaluate the associations between time-updated systolic blood pressure and time-updated change in systolic blood pressure during the follow-up period and risk of all-cause mortality in patients with type 2 diabetes and renal impairment.Patients and methods: A total of 27,732 patients with type 2 diabetes and renal impairment in the Swedish National Diabetes Register were followed for 4.7years. Time-dependent Cox models were used to estimate risk of all-cause mortality. Time-updated mean systolic blood pressure is the average of the baseline and the reported post-baseline systolic blood pressures.Results: A time-updated systolic blood pressure<130mmHg was associated with a higher risk of all-cause mortality in patients both with and without a history of chronic heart failure (hazard ratio: 1.25, 95% confidence interval: 1.13-1.40 and hazard ratio: 1.26, 1.17-1.36, respectively). A time-updated decrease in systolic blood pressure>10mmHg between the last two observations was associated with higher risk of all-cause mortality (-10 to -25mmHg; hazard ratio: 1.24, 95% confidence interval: 1.17-1.32).Conclusion: Both low systolic blood pressure and a decrease in systolic blood pressure during the follow-up are associated with a higher risk of all-cause mortality in patients with type 2 diabetes and renal impairment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Type 2 diabetes
- renal impairment
- blood pressure
- cardiovascular outcomes
- all-cause mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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