WFRF:(Talts Jan)
Sökning: WFRF:(Talts Jan) > Expression and biol...
- Ekblom, PeterLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine (författare)
Expression and biological role of laminin-1.
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
- 2003
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:d222c50f-d4ea-4c1d-8524-6e7921a489a1
- https://lup.lub.lu.se/record/113135URI
- https://doi.org/10.1016/S0945-053X(03)00015-5DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Of the approximately 15 laminin trimers described in mammals, laminin-1 expression seems to be largely limited to epithelial basement membranes. It appears early during epithelial morphogenesis in most tissues of the embryo, and remains present as a major epithelial laminin in some adult tissues. Previous organ culture studies with embryonic tissues have suggested that laminin-1 is important for epithelial development. Recent data using genetically manipulated embryonic stem (ES) cells grown as embryoid bodies provide strong support for the view of a specific role of laminin-1 in epithelial morphogenesis. One common consequence of genetic ablation of FGF signaling, beta1-integrin or laminin gamma1 chain expression in ES cells is the absence of laminin-1, which correlates with failure of BM assembly and epiblast differentiation. Partial but distinct rescue of epiblast differentiation has been achieved in all three mutants by exogenously added laminin-1. Laminin-1 contains several biologically active modules, but several are found in beta1 or gamma1 chains shared by at least 11 laminins. However, the carboxytermini of the alpha chains contain five laminin globular (LG) modules, distinct for each alpha chain. There is increasing evidence for a particular role of alpha1LG4 binding to its receptors for epithelial tubulogenesis. The biological roles of this and other domains of laminin-1 are currently being explored by genetic means. The pathways controlling laminin-1 synthesis have remained largely unknown, but recent advances raise the possibility that laminin-1 and collagen IV synthesis can be regulated by pro-survival kinases of the protein kinase B/Akt family.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- Carboxytermini
- Epithelial
- Collagen
- Tubulogenesis
- Kinases
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Lonai, Peter (författare)
- Talts, JanLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)medk-jta (författare)
- Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Matrix Biology22:1, s. 35-471569-1802
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- Ekblom, Peter
- Lonai, Peter
- Talts, Jan
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- MEDICIN OCH HÄLS ...
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- Matrix Biology
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- Lunds universitet
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