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Preclinical amyloid...
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Idland, Ane Victoria
(author)
Preclinical amyloid-β and axonal degeneration pathology in delirium
- Article/chapterEnglish2016
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LIBRIS-ID:oai:lup.lub.lu.se:d2684b63-b658-4609-bb6e-14b88ece3eaa
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https://lup.lub.lu.se/record/d2684b63-b658-4609-bb6e-14b88ece3eaaURI
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https://doi.org/10.3233/JAD-160461DOI
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https://gup.ub.gu.se/publication/246464URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134591464URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background: The clinical relevance of brain β-amyloidosis in older adults without dementia is not established. As delirium and dementia are strongly related, studies on patients with delirium may give pathophysiological clues. Objective: To determine whether the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau) are associated with delirium in hip fracture patients with and without dementia. Methods: CSF was collected in conjunction to spinal anesthesia in 129 patients. Delirium was assessed using the Confusion Assessment Method once daily in all patients, both pre- and postoperatively. The diagnosis of dementia at admission was based upon clinical consensus. CSF levels of Aβ42, T-tau, and P-tau were analyzed. Results: In patients without dementia, we found lower CSF Aβ42 levels (median, 310ng/L versus 489ng/L, p=0.006), higher T-tau levels (median, 505ng/L versus 351ng/L, p=0.02), but no change in P-tau in patients who developed delirium (n=16) compared to those who remained lucid (n=49). Delirious patients also had lower ratios of Aβ42 to T-tau (p<0.001) and P-tau (p=0.001) relative to those without delirium. CSF Aβ42 and T-tau remained significantly associated with delirium status in adjusted analyses. In patients with dementia, CSF biomarker levels did not differ between those with (n=54) and without delirium (n=10). Conclusion: The reduction in CSF Aβ42, indicating β-amyloidosis, and increase in T-tau, indicating neurodegeneration, in hip fracture patients without dementia developing delirium indicates that preclinical AD brain pathology is clinically relevant and possibly plays a role in delirium pathophysiology.
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Wyller, Torgeir BruunUniversity of Oslo
(author)
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Stoen, RandiOslo university hospital
(author)
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Eri, Lars MagneUniversity of Oslo
(author)
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Frihagen, FredeUniversity of Oslo
(author)
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Ræder, JohanOslo university hospital
(author)
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Chaudhry, Farrukh AbbasUniversity of Oslo
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Bogdanovic, NenadKarolinska Institutet
(author)
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Brækhus, AnneOslo university hospital
(author)
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Watne, L.O.University of Oslo
(author)
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University of OsloOslo university hospital
(creator_code:org_t)
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In:Journal of Alzheimer's Disease55:1, s. 371-3791387-28771875-8908
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Idland, Ane Vict ...
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Wyller, Torgeir ...
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Stoen, Randi
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Eri, Lars Magne
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Frihagen, Frede
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Ræder, Johan
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Chaudhry, Farruk ...
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Hansson, Oskar
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Brækhus, Anne
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Watne, L.O.
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