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Search: onr:"swepub:oai:lup.lub.lu.se:d2684b63-b658-4609-bb6e-14b88ece3eaa" > Preclinical amyloid...

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  • Idland, Ane Victoria (author)

Preclinical amyloid-β and axonal degeneration pathology in delirium

  • Article/chapterEnglish2016

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  • 2016
  • 9 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:d2684b63-b658-4609-bb6e-14b88ece3eaa
  • https://lup.lub.lu.se/record/d2684b63-b658-4609-bb6e-14b88ece3eaaURI
  • https://doi.org/10.3233/JAD-160461DOI
  • https://gup.ub.gu.se/publication/246464URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134591464URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background: The clinical relevance of brain β-amyloidosis in older adults without dementia is not established. As delirium and dementia are strongly related, studies on patients with delirium may give pathophysiological clues. Objective: To determine whether the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau) are associated with delirium in hip fracture patients with and without dementia. Methods: CSF was collected in conjunction to spinal anesthesia in 129 patients. Delirium was assessed using the Confusion Assessment Method once daily in all patients, both pre- and postoperatively. The diagnosis of dementia at admission was based upon clinical consensus. CSF levels of Aβ42, T-tau, and P-tau were analyzed. Results: In patients without dementia, we found lower CSF Aβ42 levels (median, 310ng/L versus 489ng/L, p=0.006), higher T-tau levels (median, 505ng/L versus 351ng/L, p=0.02), but no change in P-tau in patients who developed delirium (n=16) compared to those who remained lucid (n=49). Delirious patients also had lower ratios of Aβ42 to T-tau (p<0.001) and P-tau (p=0.001) relative to those without delirium. CSF Aβ42 and T-tau remained significantly associated with delirium status in adjusted analyses. In patients with dementia, CSF biomarker levels did not differ between those with (n=54) and without delirium (n=10). Conclusion: The reduction in CSF Aβ42, indicating β-amyloidosis, and increase in T-tau, indicating neurodegeneration, in hip fracture patients without dementia developing delirium indicates that preclinical AD brain pathology is clinically relevant and possibly plays a role in delirium pathophysiology.

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  • Wyller, Torgeir BruunUniversity of Oslo (author)
  • Stoen, RandiOslo university hospital (author)
  • Eri, Lars MagneUniversity of Oslo (author)
  • Frihagen, FredeUniversity of Oslo (author)
  • Ræder, JohanOslo university hospital (author)
  • Chaudhry, Farrukh AbbasUniversity of Oslo (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Bogdanovic, NenadKarolinska Institutet (author)
  • Brækhus, AnneOslo university hospital (author)
  • Watne, L.O.University of Oslo (author)
  • University of OsloOslo university hospital (creator_code:org_t)

Related titles

  • In:Journal of Alzheimer's Disease55:1, s. 371-3791387-28771875-8908

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