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Atopy patch test re...
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Johansson, C.Karolinska Institutet
(author)
Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients.
- Article/chapterEnglish2003
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Oxford University Press (OUP),2003
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electronicrdacarrier
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LIBRIS-ID:oai:lup.lub.lu.se:d26e2d83-f4ea-439c-bbf9-f0b87083c156
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https://lup.lub.lu.se/record/112530URI
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https://doi.org/10.1046/j.1365-2133.2003.05093.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1959055URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background The yeast Malassezia is considered to be one of the factors that can contribute to atopic dermatitis (AD). Objectives To investigate the reactivity to Malassezia allergens, measured as specific serum IgE, positive skin prick test and positive atopy patch test (APT), in adult patients with AD. Methods In total, 132 adult patients with AD, 14 with seborrhoeic dermatitis (SD) and 33 healthy controls were investigated for their reactions to M. sympodialis extract and three recombinant Malassezia allergens (rMal s 1, rMal s 5 and rMal s 6). Results Sixty-seven per cent of the AD patients, but only one of the SD patients and none of the healthy controls, showed a positive reaction to at least one of the Malassezia allergens (extract and/or recombinant allergens) in at least one of the tests. The levels of M. sympodialis-specific IgE in serum correlated with the total serum IgE levels. Elevated serum levels of M. sympodialis-specific IgE were found in 55% and positive APT reactions in 41% of the AD patients with head and neck dermatitis. A relatively high proportion of patients without head and neck dermatitis and patients with low total serum IgE levels had a positive APT for M. sympodialis, despite lower proportions of individuals with M. sympodialis-specific IgE among these groups of patients. Conclusions These results support that Malassezia can play a role in eliciting and maintaining eczema in patients with AD. The addition of an APT to the test battery used in this study reveals a previously overlooked impact of Malassezia hypersensitivity in certain subgroups of AD patients.
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Sandström, M.H.
(author)
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Bartosik, JacekLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)derm-jba
(author)
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Särnhult, T.
(author)
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Christiansen, J
(author)
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Zargari, A.Karolinska Institutet
(author)
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Bäck, OveLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)derm-oba
(author)
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Wahlgren, C.F.Karolinska Institutet
(author)
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Faergemann, J.
(author)
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Scheynius, A.Karolinska Institutet
(author)
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Tengvall Linder, M.Karolinska Institutet
(author)
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Karolinska InstitutetDermatologi och venereologi, Lund
(creator_code:org_t)
Related titles
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In:British Journal of Dermatology: Oxford University Press (OUP)148:3, s. 479-4881365-21330007-0963
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Johansson, C.
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Sandström, M.H.
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Bartosik, Jacek
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Särnhult, T.
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Christiansen, J
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Zargari, A.
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Bäck, Ove
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Wahlgren, C.F.
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Faergemann, J.
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Scheynius, A.
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Tengvall Linder, ...
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- MEDICAL AND HEALTH SCIENCES
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Lund University
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Karolinska Institutet