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Sugar-sweetened bev...
Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway : a meta-analysis
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- McKeown, Nicola M. (författare)
- Tufts University
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- Dashti, Hassan S. (författare)
- Massachusetts General Hospital,Tufts University,Broad Institute
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- Ma, Jiantao (författare)
- National Heart Lung and Blood Institute
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visa fler...
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- Haslam, Danielle E. (författare)
- Tufts University
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- Kiefte-de Jong, Jessica C. (författare)
- Leiden University,Erasmus University Medical Center
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- Smith, Caren E. (författare)
- Tufts University
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- Tanaka, Toshiko (författare)
- National Institute on Aging, United States
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- Graff, Mariaelisa (författare)
- University of North Carolina
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- Lemaitre, Rozenn N. (författare)
- University of Washington
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- Rybin, Denis (författare)
- Boston University
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- Sonestedt, Emily (författare)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Frazier-Wood, Alexis C. (författare)
- Baylor College of Medicine
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- Mook-Kanamori, Dennis O. (författare)
- Leiden University Medical Centre
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- Li, Yanping (författare)
- Harvard University
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- Wang, Carol A. (författare)
- University of Western Australia, Crawley
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- Leermakers, Elisabeth T.M. (författare)
- Erasmus University Medical Center
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- Mikkilä, Vera (författare)
- University of Helsinki,University of Turku
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- Young, Kristin L. (författare)
- University of North Carolina
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- Mukamal, Kenneth J. (författare)
- Beth Israel Deaconess Medical Center
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- Cupples, L. Adrienne (författare)
- National Heart Lung and Blood Institute,Boston University
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- Schulz, Christina Alexandra (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Chen, Tzu An (författare)
- Baylor College of Medicine
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- Li-Gao, Ruifang (författare)
- Leiden University Medical Centre
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- Huang, Tao (författare)
- Harvard University
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- Oddy, Wendy H. (författare)
- University of Tasmania,Telethon Kids Institute
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- Raitakari, Olli (författare)
- Turku University Hospital,University of Turku
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- Rice, Kenneth (författare)
- University of Washington
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- Meigs, James B. (författare)
- Massachusetts General Hospital,Harvard Medical School,Broad Institute
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- Ericson, Ulrika (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Steffen, Lyn M. (författare)
- University of Minnesota
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- Rosendaal, Frits R. (författare)
- Leiden University Medical Centre
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- Hofman, Albert (författare)
- Erasmus University Medical Center
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- Kähönen, Mika (författare)
- Tampere University Hospital
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- Psaty, Bruce M. (författare)
- Kaiser Permanente Research Institute,University of Washington
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- Brunkwall, Louise (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Uitterlinden, Andre G. (författare)
- Erasmus University Medical Center
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- Viikari, Jorma (författare)
- Turku University Hospital,University of Turku
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- Siscovick, David S. (författare)
- New York Academy of Medicine
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- Seppälä, Ilkka (författare)
- University of Tampere
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- North, Kari E. (författare)
- University of North Carolina
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- Mozaffarian, Dariush (författare)
- Tufts University
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- Dupuis, Josée (författare)
- National Heart Lung and Blood Institute,Boston University
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Rich, Stephen S. (författare)
- University of Virginia
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- de Mutsert, Renée (författare)
- Leiden University Medical Centre
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- Qi, Lu (författare)
- Harvard University
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- Pennell, Craig E. (författare)
- University of Western Australia, Crawley
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- Franco, Oscar H. (författare)
- Erasmus University Medical Center
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- Lehtimäki, Terho (författare)
- Tufts University
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- Herman, Mark A. (författare)
- Duke University
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(creator_code:org_t)
- 2017-11-02
- 2018
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 61:2, s. 317-330
- Relaterad länk:
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http://dx.doi.org/10...
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate positive associations between higher SSB intake and glycaemic traits. Methods: Data from 11 cohorts (six discovery and five replication) in the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided association and interaction results from 34,748 adults of European descent. SSB intake (soft drinks, fruit punches, lemonades or other fruit drinks) was derived from food-frequency questionnaires and food diaries. In fixed-effects meta-analyses, we quantified: (1) the associations between SSBs and glycaemic traits (fasting glucose and fasting insulin); and (2) the interactions between SSBs and 18 independent SNPs related to the ChREBP-FGF21 pathway. Results: In our combined meta-analyses of discovery and replication cohorts, after adjustment for age, sex, energy intake, BMI and other dietary covariates, each additional serving of SSB intake was associated with higher fasting glucose (β ± SE 0.014 ± 0.004 [mmol/l], p = 1.5 × 10−3) and higher fasting insulin (0.030 ± 0.005 [loge pmol/l], p = 2.0 × 10−10). No significant interactions on glycaemic traits were observed between SSB intake and selected SNPs. While a suggestive interaction was observed in the discovery cohorts with a SNP (rs1542423) in the β-Klotho (KLB) locus on fasting insulin (0.030 ± 0.011 loge pmol/l, uncorrected p = 0.006), results in the replication cohorts and combined meta-analyses were non-significant. Conclusions/interpretation: In this large meta-analysis, we observed that SSB intake was associated with higher fasting glucose and insulin. Although a suggestive interaction with a genetic variant in the ChREBP-FGF21 pathway was observed in the discovery cohorts, this observation was not confirmed in the replication analysis. Trial registration: Trials related to this study were registered at clinicaltrials.govas NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005121 (Framingham Offspring Study), NCT00005487 (Multi-Ethnic Study of Atherosclerosis) and NCT00005152 (Nurses’ Health Study).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Carbohydrate metabolism
- Epidemiology
- Genetics
- Meta-analysis
- Nutrition
- Type 2 diabetes
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- Av författaren/redakt...
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McKeown, Nicola ...
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Dashti, Hassan S ...
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Ma, Jiantao
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Haslam, Danielle ...
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Kiefte-de Jong, ...
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Smith, Caren E.
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visa fler...
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Tanaka, Toshiko
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Graff, Mariaelis ...
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Lemaitre, Rozenn ...
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Rybin, Denis
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Sonestedt, Emily
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Frazier-Wood, Al ...
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Mook-Kanamori, D ...
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Li, Yanping
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Wang, Carol A.
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Leermakers, Elis ...
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Mikkilä, Vera
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Young, Kristin L ...
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Mukamal, Kenneth ...
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Cupples, L. Adri ...
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Schulz, Christin ...
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Chen, Tzu An
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Li-Gao, Ruifang
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Huang, Tao
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Oddy, Wendy H.
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Raitakari, Olli
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Rice, Kenneth
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Meigs, James B.
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Ericson, Ulrika
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Steffen, Lyn M.
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Rosendaal, Frits ...
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Hofman, Albert
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Kähönen, Mika
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Psaty, Bruce M.
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Brunkwall, Louis ...
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Uitterlinden, An ...
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Viikari, Jorma
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Siscovick, David ...
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Seppälä, Ilkka
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North, Kari E.
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Mozaffarian, Dar ...
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Dupuis, Josée
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Orho-Melander, M ...
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Rich, Stephen S.
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de Mutsert, René ...
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Qi, Lu
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Pennell, Craig E ...
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Franco, Oscar H.
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Lehtimäki, Terho
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Herman, Mark A.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Lunds universitet