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Search: id:"swepub:oai:lup.lub.lu.se:d3267e34-3a2c-4baf-9849-3c6b0af601c2" > FLT3 mutations conf...

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  • Lee, Benjamin H. (author)

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier BV,2007

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  • LIBRIS-ID:oai:lup.lub.lu.se:d3267e34-3a2c-4baf-9849-3c6b0af601c2
  • https://lup.lub.lu.se/record/654162URI
  • https://doi.org/10.1016/j.ccr.2007.08.031DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.

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  • Tothova, Zuzana (author)
  • Levine, Ross L. (author)
  • Anderson, KristinaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-kan (author)
  • Buza-Vidas, NatalijaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-nbu (author)
  • Cullen, Dana E. (author)
  • McDowell, Elizabeth P. (author)
  • Adelsperger, Jennifer (author)
  • Frhling, Stefan (author)
  • Huntly, Brian J. P. (author)
  • Beran, Miloslav (author)
  • Jacobsen, Sten Eirik WLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-sja (author)
  • Gilliland, D. Gary (author)
  • Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

Related titles

  • In:Cancer Cell: Elsevier BV12:4, s. 367-3801878-36861535-6108

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