Search: id:"swepub:oai:lup.lub.lu.se:d3267e34-3a2c-4baf-9849-3c6b0af601c2" >
FLT3 mutations conf...
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Lee, Benjamin H.
(author)
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
- Article/chapterEnglish2007
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LIBRIS-ID:oai:lup.lub.lu.se:d3267e34-3a2c-4baf-9849-3c6b0af601c2
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https://lup.lub.lu.se/record/654162URI
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https://doi.org/10.1016/j.ccr.2007.08.031DOI
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Language:English
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Summary in:English
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Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.
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Tothova, Zuzana
(author)
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Levine, Ross L.
(author)
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Anderson, KristinaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-kan
(author)
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Buza-Vidas, NatalijaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-nbu
(author)
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Cullen, Dana E.
(author)
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McDowell, Elizabeth P.
(author)
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Adelsperger, Jennifer
(author)
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Frhling, Stefan
(author)
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Huntly, Brian J. P.
(author)
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Beran, Miloslav
(author)
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Jacobsen, Sten Eirik WLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-sja
(author)
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Gilliland, D. Gary
(author)
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Stamcellscentrum (SCC)Avdelningen för stamcellsforskning
(creator_code:org_t)
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In:Cancer Cell: Elsevier BV12:4, s. 367-3801878-36861535-6108
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Lee, Benjamin H.
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Tothova, Zuzana
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Levine, Ross L.
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Anderson, Kristi ...
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Buza-Vidas, Nata ...
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Cullen, Dana E.
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McDowell, Elizab ...
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Adelsperger, Jen ...
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Frhling, Stefan
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Huntly, Brian J. ...
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Beran, Miloslav
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Jacobsen, Sten E ...
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Gilliland, D. Ga ...
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- MEDICAL AND HEALTH SCIENCES
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Cancer Cell
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Lund University