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EURO-B.O.S.S. : A E...
EURO-B.O.S.S. : A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma
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- Ferrari, Stefano (author)
- Rizzoli Orthopedic Institute
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- Bielack, Stefan S. (author)
- Klinikum Stuttgart Olgahospital,Oslo university hospital
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- Smeland, Sigbjørn (author)
- Oslo university hospital
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- Longhi, Alessandra (author)
- Rizzoli Orthopedic Institute
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- Egerer, Gerlinde (author)
- University Hospital Heidelberg
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- Sundby Hall, Kirsten (author)
- Oslo university hospital
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- Donati, Davide (author)
- Rizzoli Orthopedic Institute
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- Kevric, Matthias (author)
- Klinikum Stuttgart Olgahospital
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- Brosjö, Otte (author)
- Karolinska University Hospital
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- Comandone, Alessandro (author)
- Ospedale Humanitas Gradenigo
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- Werner, Mathias (author)
- HELIOS Klinikum Emil von Behring
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- Monge, Odd (author)
- Haukeland University Hospital
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- Palmerini, Emanuela (author)
- Rizzoli Orthopedic Institute
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- Berdel, Wolfgang E. (author)
- University Hospital Münster
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- Bjerkehagen, Bodil (author)
- Oslo university hospital
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- Paioli, Anna (author)
- Rizzoli Orthopedic Institute
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- Lorenzen, Sylvie (author)
- Technical University of Munich
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gambarotti, Marco (author)
- Rizzoli Orthopedic Institute
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- Tunn, Per Ulf (author)
- HELIOS Klinikum Berlin-Buch
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- Jebsen, Nina L. (author)
- Haukeland University Hospital
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- Cesari, Marilena (author)
- Rizzoli Orthopedic Institute
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- von Kalle, Thekla (author)
- Klinikum Stuttgart Olgahospital
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- Ferraresi, Virginia (author)
- National Cancer Institute Regina Elena
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- Schwarz, Rudolf (author)
- University Medical Center Hamburg-Eppendorf
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- Bertulli, Rossella (author)
- Istituto Nazionale dei Tumori
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- Kasparek, Anne Katrin (author)
- Medical University of Graz
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- Grignani, Giovanni (author)
- Institute for Cancer Research and Treatment, Candiolo
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- Krasniqi, Fatime (author)
- University Hospital Basel
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- Sorg, Benjamin (author)
- Klinikum Stuttgart Olgahospital
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- Hecker-Nolting, Stefanie (author)
- Klinikum Stuttgart Olgahospital
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- Picci, Piero (author)
- Rizzoli Orthopedic Institute
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- Reichardt, Peter (author)
- HELIOS Klinikum Emil von Behring
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(creator_code:org_t)
- 2018-04-27
- 2018
- English 7 s.
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In: Tumori. - : SAGE Publications. - 0300-8916 .- 2038-2529. ; 104:1, s. 30-36
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.5...
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Abstract
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- INTRODUCTION: The EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) was the first prospective international study for patients 41-65 years old with high-grade bone sarcoma treated with an intensive chemotherapy regimen derived from protocols for younger patients with high-grade skeletal osteosarcoma.METHODS: Chemotherapy based on doxorubicin, cisplatin, ifosfamide, and methotrexate was suggested, but patients treated with other regimens at the investigators' choice were also eligible for the study.RESULTS: The present report focuses on the subgroup of 218 patients with primary high-grade osteosarcoma. With a median follow-up of 47 months, the 5-year probability of overall survival (OS) was 66% in patients with localized disease and 22% in case of synchronous metastases. The 5-year OS in patients with localized disease was 29% in pelvic tumors, and 70% and 73% for extremity or craniofacial locations, respectively. In primary chemotherapy, tumor necrosis ≥90% was reported in 21% of the patients. There were no toxic deaths; however, hematological toxicity was considerable with 32% of patients experiencing 1 or more episodes of neutropenic fever. The incidence of nephrotoxicity and neurotoxicity (mainly peripheral) was 28% and 24%, respectively. After methotrexate, 23% of patients experienced delayed excretion, in 4 cases with nephrotoxicity.CONCLUSIONS: In patients over 40 years of age with primary high-grade osteosarcoma, an aggressive approach with chemotherapy and surgery can offer the probability of survival similar to that achieved in younger patients. Chemotherapy-related toxicity is significant and generally higher than that reported in younger cohorts of osteosarcoma patients treated with more intensive regimens.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult osteosarcoma
- Chemotherapy
- Chemotherapy-related toxicity
- Osteosarcoma
Publication and Content Type
- art (subject category)
- ref (subject category)
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Ferrari, Stefano
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Bielack, Stefan ...
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Smeland, Sigbjør ...
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Longhi, Alessand ...
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Egerer, Gerlinde
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Sundby Hall, Kir ...
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Donati, Davide
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Kevric, Matthias
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Brosjö, Otte
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Comandone, Aless ...
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Werner, Mathias
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Monge, Odd
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Palmerini, Emanu ...
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Berdel, Wolfgang ...
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Bjerkehagen, Bod ...
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Paioli, Anna
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Lorenzen, Sylvie
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Eriksson, Mikael
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Gambarotti, Marc ...
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Tunn, Per Ulf
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Jebsen, Nina L.
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Cesari, Marilena
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von Kalle, Thekl ...
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Ferraresi, Virgi ...
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Schwarz, Rudolf
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Bertulli, Rossel ...
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Kasparek, Anne K ...
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Grignani, Giovan ...
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Krasniqi, Fatime
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Sorg, Benjamin
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Hecker-Nolting, ...
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Picci, Piero
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Reichardt, Peter
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- MEDICAL AND HEALTH SCIENCES
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Tumori
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Tumori Journal
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Lund University
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Karolinska Institutet