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  • Ferrari, StefanoRizzoli Orthopedic Institute (author)

EURO-B.O.S.S. : A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-04-27
  • SAGE Publications,2018
  • 7 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:d36a79e0-6ca9-4cd2-a167-fc7a2bd1fef6
  • https://lup.lub.lu.se/record/d36a79e0-6ca9-4cd2-a167-fc7a2bd1fef6URI
  • https://doi.org/10.5301/tj.5000696DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138473971URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • INTRODUCTION: The EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) was the first prospective international study for patients 41-65 years old with high-grade bone sarcoma treated with an intensive chemotherapy regimen derived from protocols for younger patients with high-grade skeletal osteosarcoma.METHODS: Chemotherapy based on doxorubicin, cisplatin, ifosfamide, and methotrexate was suggested, but patients treated with other regimens at the investigators' choice were also eligible for the study.RESULTS: The present report focuses on the subgroup of 218 patients with primary high-grade osteosarcoma. With a median follow-up of 47 months, the 5-year probability of overall survival (OS) was 66% in patients with localized disease and 22% in case of synchronous metastases. The 5-year OS in patients with localized disease was 29% in pelvic tumors, and 70% and 73% for extremity or craniofacial locations, respectively. In primary chemotherapy, tumor necrosis ≥90% was reported in 21% of the patients. There were no toxic deaths; however, hematological toxicity was considerable with 32% of patients experiencing 1 or more episodes of neutropenic fever. The incidence of nephrotoxicity and neurotoxicity (mainly peripheral) was 28% and 24%, respectively. After methotrexate, 23% of patients experienced delayed excretion, in 4 cases with nephrotoxicity.CONCLUSIONS: In patients over 40 years of age with primary high-grade osteosarcoma, an aggressive approach with chemotherapy and surgery can offer the probability of survival similar to that achieved in younger patients. Chemotherapy-related toxicity is significant and generally higher than that reported in younger cohorts of osteosarcoma patients treated with more intensive regimens.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bielack, Stefan S.Klinikum Stuttgart Olgahospital,Oslo university hospital (author)
  • Smeland, SigbjørnOslo university hospital (author)
  • Longhi, AlessandraRizzoli Orthopedic Institute (author)
  • Egerer, GerlindeUniversity Hospital Heidelberg (author)
  • Sundby Hall, KirstenOslo university hospital (author)
  • Donati, DavideRizzoli Orthopedic Institute (author)
  • Kevric, MatthiasKlinikum Stuttgart Olgahospital (author)
  • Brosjö, OtteKarolinska University Hospital (author)
  • Comandone, AlessandroOspedale Humanitas Gradenigo (author)
  • Werner, MathiasHELIOS Klinikum Emil von Behring (author)
  • Monge, OddHaukeland University Hospital (author)
  • Palmerini, EmanuelaRizzoli Orthopedic Institute (author)
  • Berdel, Wolfgang E.University Hospital Münster (author)
  • Bjerkehagen, BodilOslo university hospital (author)
  • Paioli, AnnaRizzoli Orthopedic Institute (author)
  • Lorenzen, SylvieTechnical University of Munich (author)
  • Eriksson, MikaelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-mer (author)
  • Gambarotti, MarcoRizzoli Orthopedic Institute (author)
  • Tunn, Per UlfHELIOS Klinikum Berlin-Buch (author)
  • Jebsen, Nina L.Haukeland University Hospital (author)
  • Cesari, MarilenaRizzoli Orthopedic Institute (author)
  • von Kalle, TheklaKlinikum Stuttgart Olgahospital (author)
  • Ferraresi, VirginiaNational Cancer Institute Regina Elena (author)
  • Schwarz, RudolfUniversity Medical Center Hamburg-Eppendorf (author)
  • Bertulli, RossellaIstituto Nazionale dei Tumori (author)
  • Kasparek, Anne KatrinMedical University of Graz (author)
  • Grignani, GiovanniInstitute for Cancer Research and Treatment, Candiolo (author)
  • Krasniqi, FatimeUniversity Hospital Basel (author)
  • Sorg, BenjaminKlinikum Stuttgart Olgahospital (author)
  • Hecker-Nolting, StefanieKlinikum Stuttgart Olgahospital (author)
  • Picci, PieroRizzoli Orthopedic Institute (author)
  • Reichardt, PeterHELIOS Klinikum Emil von Behring (author)
  • Rizzoli Orthopedic InstituteKlinikum Stuttgart Olgahospital (creator_code:org_t)

Related titles

  • In:Tumori: SAGE Publications104:1, s. 30-360300-89162038-2529
  • In:Tumori Journal: SAGE Publications104:1, s. 30-362038-2529

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