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Systematic review a...
Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP) : Study protocol
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- Seidler, Anna Lene (author)
- University of Sydney
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- Duley, Lelia (author)
- University of Nottingham
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- Katheria, Anup C. (author)
- Sharp Mary Birch Hospital for Women & Newborns, Sharp HealthCare
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- De Paco Matallana, Catalina (author)
- Hospital Virgen de la Arrixaca
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- Dempsey, Eugene (author)
- Cork University Hospital
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- Rabe, Heike (author)
- Brighton and Sussex University Hospitals NHS Trust
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- Kattwinkel, John (author)
- University of Virginia
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- Mercer, Judith (author)
- University of Rhode Island
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- Josephsen, Justin (author)
- Saint Louis University School of Medicine
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- Fairchild, Karen (author)
- University of Virginia
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- Andersson, Ola (author)
- Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital
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- Hosono, Shigeharu (author)
- Jichi Medical University
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- Sundaram, Venkataseshan (author)
- Postgraduate Institute of Medical Education and Research
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- Datta, Vikram (author)
- University of Delhi
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- El-Naggar, Walid (author)
- Dalhousie University
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- Tarnow-Mordi, William (author)
- University of Sydney
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- Debray, Thomas (author)
- University Medical Center Utrecht
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- Hooper, Stuart B. (author)
- Monash University
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- Kluckow, Martin (author)
- University of Sydney
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- Polglase, Graeme (author)
- Monash University
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- Davis, Peter G. (author)
- The Royal Women's Hospital
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- Montgomery, Alan (author)
- University of Nottingham
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- Hunter, Kylie E. (author)
- University of Sydney
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- Barba, Angie (author)
- University of Sydney
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- Simes, John (author)
- University of Sydney
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- Askie, Lisa (author)
- University of Sydney
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(creator_code:org_t)
- 2020-03-29
- 2020
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 10:3
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Abstract
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- Introduction: Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare various policies, including time-based or physiology-based deferred cord clamping, and cord milking. Individual participant data (IPD) enable exploration of different strategies within subgroups. Network meta-analysis (NMA) enables comparison and ranking of all available interventions using a combination of direct and indirect comparisons. Objectives: (1) To evaluate the effectiveness of cord management strategies for preterm infants on neonatal mortality and morbidity overall and for different participant characteristics using IPD meta-analysis. (2) To evaluate and rank the effect of different cord management strategies for preterm births on mortality and other key outcomes using NMA. Methods and analysis: Systematic searches of Medline, Embase, clinical trial registries, and other sources for all ongoing and completed randomised controlled trials comparing cord management strategies at preterm birth (before 37 weeks' gestation) have been completed up to 13 February 2019, but will be updated regularly to include additional trials. IPD will be sought for all trials; aggregate summary data will be included where IPD are unavailable. First, deferred clamping and cord milking will be compared with immediate clamping in pairwise IPD meta-analyses. The primary outcome will be death prior to hospital discharge. Effect differences will be explored for prespecified participant subgroups. Second, all identified cord management strategies will be compared and ranked in an IPD NMA for the primary outcome and the key secondary outcomes. Treatment effect differences by participant characteristics will be identified. Inconsistency and heterogeneity will be explored. Ethics and dissemination: Ethics approval for this project has been granted by the University of Sydney Human Research Ethics Committee (2018/886). Results will be relevant to clinicians, guideline developers and policy-makers, and will be disseminated via publications, presentations and media releases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- individual participant data meta-analysis
- network meta-analysis
- placental transfusion
- preterm birth
- prospective meta-analysis
- umbilical cord clamping
- umbilical cord milking
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- By the author/editor
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Seidler, Anna Le ...
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Duley, Lelia
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Katheria, Anup C ...
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De Paco Matallan ...
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Dempsey, Eugene
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Rabe, Heike
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Kattwinkel, John
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Mercer, Judith
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Josephsen, Justi ...
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Fairchild, Karen
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Andersson, Ola
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Hosono, Shigehar ...
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Sundaram, Venkat ...
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Datta, Vikram
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El-Naggar, Walid
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Tarnow-Mordi, Wi ...
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Debray, Thomas
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Hooper, Stuart B ...
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Kluckow, Martin
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Polglase, Graeme
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Davis, Peter G.
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Montgomery, Alan
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Hunter, Kylie E.
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Barba, Angie
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Simes, John
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Askie, Lisa
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BMJ Open
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