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Sökning: WFRF:(Mahr Alfred) > (2015-2019) > Damage in the anca-...

  • Robson, Joanna (författare)

Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2013-11-15
  • BMJ,2015

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d4a4d641-f5c8-4122-81dd-0bd455b0bfda
  • https://lup.lub.lu.se/record/4962568URI
  • https://doi.org/10.1136/annrheumdis-2013-203927DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objectives To describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV). Methods Data were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Damage Index (VDI). Sixteen damage items were defined a priori as being potentially treatment-related. Results VDI data were available for 629 of 735 patients (85.6%) at baseline, at which time 217/629 (34.5%) had >= 1 item of damage and 32 (5.1%) >= 5 items, reflecting disease manifestations prior to diagnosis and trial enrolment. LTFU data were available for 467/535 (87.3%) at a mean of 7.3 years postdiagnosis. 302/535 patients (56.4%) had VDI data at LTFU, with 104/302 (34.4%) having >= 5 items and only 24 (7.9%) no items of damage. At 6 months and LTFU, the most frequent items were proteinuria, impaired glomerular filtration rate, hypertension, nasal crusting, hearing loss and peripheral neuropathy. The frequency of damage, including potentially treatment-related damage, rose over time (p<0.01). At LTFU, the most commonly reported items of treatment-related damage were hypertension (41.5%; 95% CI 35.6 to 47.4%), osteoporosis (14.1%; 9.9 to 18.2%), malignancy (12.6%; 8.6 to 16.6%), and diabetes (10.4%; 6.7 to 14.0%). Conclusions In AAV, renal, otolaryngological and treatment-related (cardiovascular, disease, diabetes, osteoporosis and malignancy) damage increases over time, with around one-third of patients having >= 5 items of damage at a mean of 7 years postdiagnosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Doll, Helen (författare)
  • Suppiah, Ravi (författare)
  • Flossmann, Oliver (författare)
  • Harper, Lorraine (författare)
  • Hoglund, Peter (författare)
  • Jayne, David (författare)
  • Mahr, Alfred (författare)
  • Westman, KerstinLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-kwe (författare)
  • Luqmani, Raashid (författare)
  • NjurmedicinSektion II (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of the Rheumatic Diseases: BMJ74:1, s. 177-1841468-20600003-4967

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